| 免疫衰老及其在肿瘤中的作用 |
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| 引用本文： | 田建辉,罗斌,刘嘉湘.免疫衰老及其在肿瘤中的作用[J].国际肿瘤学杂志,2016,43(2):122-125. |
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| 作者姓名： | 田建辉 罗斌 刘嘉湘 |
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| 作者单位： | 1. 200032,上海中医药大学附属龙华医院肿瘤科;2. 上海中医药大学研究生院 |
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| 基金项目： | 国家自然科学基金，第一批全国中医药传承博士后项目，上海中医药大学附属龙华医院“龙医团队”建设项目 |
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| 摘 要： | 免疫衰老是指机体随着年龄增长而出现的免疫器官、免疫细胞等的结构与功能性衰退,导致免疫监视能力下降,从而引起肿瘤免疫逃逸发生,促使癌症的发生发展.机体固有免疫功能衰退表现在巨噬细胞和自然杀伤细胞对肿瘤细胞的直接清除作用减弱,树突状细胞的肿瘤抗原呈递能力下降;而获得性免疫功能的衰退主要表现在CD8+T细胞毒性的下降并分泌促肿瘤生长因子.干预免疫衰老可为临床肿瘤防治提供新思路.
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| 关 键 词： | 免疫 衰老 肿瘤 免疫 天然 免疫 母体获得性 肿瘤逃逸 |
Immunosenescence and its role in cancer |
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| Institution: | Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| Abstract: | Immunosenescence is a biological process featured by the structural and functional decline of immunity in ageing people,which favors the carcinogenesis by rendering the body's immune surveillance and tumor escape.Decreasing clearance of tumor cells by macrophages and natural killer cell reflects the immunosenescence of innate immune,also,the tumor antigen presentation ability of dendritic cell is decreased.While,the decline of the CD8 + T cells cytotoxic effect and the secretion of tumor growth factor accounts for the immunosenescence of adaptive immunity.Intervention of immunosenescence may produce the novelty ideas of prevention and treatment of cancer. |
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| Keywords: | Immunity Aging Neoplasms Immunity natural Immunity maternally-acquired Tumor escape |
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