氯吡格雷与阿司匹林联用治疗脑梗死的效果观察

目的观察氯吡格雷联合阿司匹林治疗脑梗死的临床效果。方法选取脑梗死患者70例,随机分为观察组(35例)和对照组(35例),观察组给予氯吡格雷联合阿司匹林治疗,对照组单独给予阿司匹林治疗,观察2组总有效率及治疗前后实验室指标。结果观察组治疗后基本痊愈6例,显效17例,有效10例,总有效率94.29%;对照组基本痊愈2例,显效11例,有效8例,总有效率60.00%,观察组总有效率明显高于对照组,差异有统计学意义(P0.05)。治疗30d后观察组血小板(PLT)、血小板聚集率(PA)及全血黏度(高切、低切)指标均明显低于对照组,差异有统计学意义(P0.05)。结论氯吡格雷联合阿司匹林治疗脑梗死临床效果显著,值得临床推广。

Observation on the clinical effect of clopidogrel and aspirin for cerebral infarction

Objective To observe the clinical effect of clopidogrel and aspirin in treating cerebral infarction.Methods Sev-enty cases of patients with cerebral infarction in our hospital from Mar.2013 to Mar.2014 were chosen,who were divided into the observation group (35 cases)and the control group (35 cases).The observation group was given the combination of clopi-dogrel and aspirin,and the observation group was given aspirin.The total efficiency and laboratory indexes before and after treatment of the two groups were compared.Results In the observation group,6 cases were cured,1 7 cases were markedly effec-tive,10 cases were effective,and the total effective rate was 94.29%;in the control group,2 cases were cured,1 1 cases were markedly effective,8 cases were effective,and the total effective rate was 60.00%.The total efficiency of the observation group was higher than that of the control group.The index of platelet (PLT),platelet aggregation rate (PA)and whole blood viscosity (high shear,low shear)of the observation group was lower than that of the control group with sodium ozagrel.Con-clusion Clopidogrel and aspirin have an obvious clinical effect for cerebral infarction patients,which should be promoted.