HPV病毒16型感染的影响因素研究

目的 探讨人乳头瘤病毒(HPV) 16型感染的相关影响因素.方法 采用调查问卷的方式对1500例自愿进行宫颈脱落细胞HPV检测的筛查者进行调查,收集筛查者的基本信息、婚育史、月经情况、性行为情况、饮酒史、吸烟史、妇科手术史、卫生情况等,采用x2检验与多因素Logistic回归分析HPV病毒16型感染的相关影响因素.结果 1500例筛查者中,HPV阳性率为12.8％(192/1500),主要类型包含HPV16型40.1％(77/192),HPV58型16.7％(32/192),HPV18型10.4％(20/192).单因素分析结果显示,HPV16型感染的相关影响因素是吸烟史、很少进行妇科检查、首次性交年龄＜25、怀孕次数≥2、流产次数≥3、妇科手术史、性伴侣数目≥2.多因素Logistic回归分析结果显示,HPV16型感染的危险因素是吸烟史、首次性交年龄＜25、妇科手术史.结论 HPV16型感染的危险因素是吸烟史、首次性交年龄＜25、妇科手术史,应尽量避免.

Study on the influencing factors of HPV 16 infections

Objective To explore the factors related to human papillomavirus (HPV) type 16 infections.Methods The questionnaire survey of 1500 subjects from the voluntary cervical shedding cells screening program of HPV was conducted to collect information of demography,marriage,pregnancy,menstruation,sexual behavior,alcohol intake,,cigarette smoking,gynecological surgery,sanitation,etc.The influencing factors of HPV type 16 infection was analyzed by chi square test and logistic regression analysis.Results Among the 1500 subjects,the positive rate of HPV was 12.8％ (192/1500).The main HPV types were HPV 16(40.1％,77/192),HPV 58 (16.7％,32/192) and HPV 18 (10.4％,20/192).Unifactor variance analysis revealed that the related factors of HPV16 infections were cigarette smoking,infrequent gynecological examination,first sexual intercourse before twenty-five years of age,2 or more times of pregnancy,3 or more times of abortion,history of gynecological operations,2 or more sexual partner.Logistic regression analysis showed that the risk factors of HPV16 infections were cigarette smoking,first sexual intercourse before twenty-five years of age,,and history of gynecological operations.Conclusions The risk factors of HPV16 infection is cigarette smoking,first sexual intercourse before twenty-five years of age,,and history of gynecological operations,and should be avoided as far as possible.