血清HBsAg与HBV DNA水平与乙肝患者肝纤维化程度的相关性分析

目的 探讨血清HBsAg与HBV DNA对乙肝患者肝纤维化的相关性分析.方法 选取2010年5月至2014年9月在我院进行治疗的100例肝脏穿刺活组织学检查的患者,根据肝脏炎症程度将患者分为G0-G1、G2、G3-G4三组,根据不同纤维化分期将患者分为S0-S1、S2、S3、S4四组,根据丙氨酸转氨酶(ALT)水平,将患者分为A1 (ALT≤40U/L)组、A2(40＜ALT≤80U/L)组,对不同分组患者进行血清HBsAg测定、HBV DNA测定及ALT测定,分析其含量与肝脏炎症程度及纤维化程度的相关性.结果 G0-G1组、G2组、G3-G4组HBsAg定量分别为(3.85±0.87)U/ml、(3.54±0.79) U/ml、(2.79 ±0.58) U/ml,三组间具有统计学差异(P＜0.05).G0-G1组、G2组、G3-G4组HBV DNA定量分别为(6.27±1.67) U/ml、(5.68±1.49) U/ml、(5.84±1.59) U/ml,三组间差异无统计学差异(P＞0.05).S0-S1组、S2组、S3组、S4组患者HBsAg定量分别为(3.95±0.93) U/ml、(3.62±0.86) U/ml、(3.55±0.62) U/ml、(3.35 ±0.54) U/ml,四组差异有统计学差异(P＜0.05).S0-S1组、S2组、S3组、S4组患者HBV DNA定量分别为(6.23±1.72) U/ml、(5.79±1.62U/ml)、(5.50±1.48) U/ml、(5.48±1.35U/ml),四组差异有统计学意义(P＜0.05).ALT水平与炎症程度及纤维化程度没有相关性(P＞0.05).结论 HBsAg、乙肝病毒随着肝纤维化程度的加重逐渐减低,血清HBsAg结合HBV DNA载量作为检测乙肝病毒感染者肝纤维化指标更为可靠.

Correlation among HBsAg and HBV DNA levels with liver fibrosis in patients with hepatitis B

Objective To explore the correlation among the levels of serum HBsAg and HBV DNA and liver fibrosis of patients with hepatitis B.Methods From May 2010 to September 2014,100 patients diagnosed as hepatitis B in our hospital were selected as research subjects.The patients were divided into three groups as G0-G1,G2,G3-G4,according to the degree of liver inflammation,and were divided into four groups as S0-S1,S2,S3,S4 based on the stage of fibrosis,and were divided into two groups as A1,A2 according to the alanine aminotransferase ALT (ALT≤2ULN).Serum HBsAg,HBV DNA and ALT were detected and the their relationship with inflammation degree and liver fibrosis were analyzed.Results The levels of serum HBsAg were (3.85 ± 0.87) U/ml,(3.54 ± 0.79) U/ml,(2.79 ± 0.58) U/ml in G0-G1,G2 and G3-G4 group,respectively.There was a statistically significant difference among the three groups (P ＜0.05).The levels of HBV DNA were (6.27 ± 1.67) U/ml,(5.68 ± 1.49) U/ml,(5.84± 1.59) U/ml in G0-G1,G2 and G3-G4 group,respectively,and there was no significant difference (P ＞0.05).The levels of serum HBsAgwere (3.95 ± 0.93) U/ml,(3.62 ± 0.86) U/ml,(3.55 ± 0.62) U/ml,(3.35 ± 0.54) U/ml in S0-S1,S2 and S3 Group,respectively and there was a statistically significant difference among the three groups (P ＜0.05).The levels of serum HBsAg were (6.23 ± 1.72) U/ml,(5.79 ± 1.62) U/ml,(5.50 ± 1.48) U/ml,(5.48 ± 1.35) U/ml in S0-S1,S2 and S3 group,respectively and there was statistically significant difference among the three groups (P ＜ 0.05).The levels of ALT showed no significant correlation with inflammation degree and liver fibrosis (P ＞ 0.05).Conclusions The levels of HBsAg and HBV DNA decreased as the degree of liver fibrosis increasing.Serum HBsAg combined with HBV DNA may assist clinical diagnosis.