Leptin facilitates lordosis behavior through GnRH-1 and progestin receptors in estrogen-primed rats |
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Authors: | García-Juárez Marcos Beyer Carlos Soto-Sánchez Alfonso Domínguez-Ordoñez Raymundo Gómora-Arrati Porfirio Lima-Hernández Francisco Javier Eguibar José R Etgen Anne M González-Flores Oscar |
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Affiliation: | a Centro de Investigación en Reproducción Animal, Universidad Autónoma de Tlaxcala-CINVESTAV, Apdo. 62, Tlaxcala, Mexico b Maestría en Ciencias Biológicas-UAT, Tlaxcala, Tlax 90140, Mexico c Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Apdo. Postal 406. Puebla, Pue. C.P. 72000, Mexico d D.P. Purpura Department of Neuroscience F113, Albert Einstein College of Medicine, Bronx, NY 10461, USA |
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Abstract: | Dose response curves for leptin facilitation of estrous behavior (lordosis and proceptivity) were made by infusing the peptide into the lateral ventricle (icv) of ovariectomized (ovx), ad libitum-fed rats injected 40 h previously with 5 μg of estradiol benzoate. Leptin doses of 1 and 3 μg produced significant lordosis quotient at 60 min post-injection, with maximal lordosis being displayed at 120 min. Yet the intensity of lordosis was weak, and a high incidence of rejection behaviors was found. Moreover, leptin did not induce significant proceptive behaviors at any dose. The leptin doses of 1 and 3 μg were selected for determining whether antide, a GnRH-1 receptor antagonist, or the progestin receptor antagonist RU486 could modify the lordosis response to leptin. Icv injection of either antide or RU486 1 h before leptin significantly depressed leptin facilitation of lordosis. The results suggest that leptin stimulates lordosis by releasing GnRH, which in turn activates GnRH-1 and progestin receptors. The physiological role of leptin in the control of estrous behavior remains to be determined. |
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Keywords: | Leptin Lordosis behavior Proceptive behavior Rejection behavior GnRH-1 receptor Progestin receptor Antide RU486 |
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