| 大鼠正畸移动牙根吸收组织内胶原酶-3的表达与分布 |
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| 引用本文： | 张志菲,刘月华. 大鼠正畸移动牙根吸收组织内胶原酶-3的表达与分布[J]. 临床口腔医学杂志, 2007, 23(3): 145-147 |
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| 作者姓名： | 张志菲 刘月华 |
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| 作者单位： | 同济大学口腔医学院口腔正畸科,上海,200072;同济大学口腔医学院口腔正畸科,上海,200072 |
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| 摘 要： | 目的：检测正畸移动牙齿根吸收组织中胶原酶-3（MMP-13）的蛋白表达及其分布,探讨正畸牙根吸收的生物学机制.方法：选用24只SD大鼠建立正畸牙移动根吸收的动物模型,随机分为空白对照组、受力7 d组、10 d组、14 d组.应用免疫组化技术检测并比较各组中MMP-13在第一磨牙根吸收组织中的定位表达,同时比较其在根吸收组织与正常根周组织中表达的差异.结果：MMP-13主要表达于成纤维细胞、成骨细胞、骨细胞及成牙骨质细胞内.但在破骨细胞和破牙细胞内并不显示MMP-13免疫活性.MMP-13在牙根吸收组织中的表达明显高于正常根周组织.结论：MMP-13作为一种重要的蛋白质分解酶可能参与了正畸移动过程中牙根吸收.
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| 关 键 词： | 胶原酶-3 牙根吸收 口腔正畸 |
| 文章编号： | 1003-1634（2007）03-0145-03 |
| 修稿时间： | 2007-01-15 |
Expression and distribution of MMp-13 in rat root-resorbing tissue induced by orthodontic tooth movement |
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| Zhang Zhi-fei,Liu Yue-hua. Expression and distribution of MMp-13 in rat root-resorbing tissue induced by orthodontic tooth movement[J]. Journal of Clinical Stomatology, 2007, 23(3): 145-147 |
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| Authors: | Zhang Zhi-fei Liu Yue-hua |
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| Affiliation: | Department of Orthodontics,School of Stomatology, Tonal University, Shanghai 200072, China |
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| Abstract: | Objective:To investigate the expression and the localization of collagenase-3 in root-resorbing tissue and to elucidate the protein changes and mechanism of root resorption induced by orthodontic tooth movement.Method:24 SD male rats were randomly grouped according to tooth movement days of 0,7,10 and 14 d.The localization of MMP-13 in rat root-resorbing tissue of the first molar was investigated by immunohistochemistry.Result:MMP-13 was detected in fibroblastic cells,cementoblasts and osteoblasts,but not in odontoclasts or osteoclasts.Moreover,MMP-13 expression was stronglier positive in the root-resorbing tissue relative to the control group.Conclusion:These results suggested that MMP-13 may play an important role in degradation of extracellular matrix in root resorption during orthodontic tooth movement. |
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| Keywords: | MMp-13 root resorption orthodontics |
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