Antiplatelet action of ilexoside D,a triterpenoid saponin fromIlex pubescens |
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Authors: | Dug Keun Lee Hye Sun Lee Min Do Huh Chul Hoon Lee Young Su Lee Hyun Su Kim Yong Nam Han |
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Institution: | 1. Cheil Foods and Chemicals R & D Center, 467-810, Ichon 2. Natural Products Research Institute, Seoul National University, 110-460, Seoul, Korea
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Abstract: | The anti-platelet activity of ilexoside D isolated from the roots ofIlex pubescens Hook. et Arn. was investigated inin vitro andex vivo models of platelet aggregation induced by ADP, thrombin or collagen in rats.In vitro ilexoside D inhibited more effectively platelet aggregation induced by ADP and thrombin than by collagen as compared with aspirin.Ex vivo ilexoside D also inhibited platelet aggregation induced by ADP and collagen, but not by thrombin, and the inhibitory action of ilexoside D was more effective than that of aspirin. However,in vitro ilexoside D inhibited very poorly the generation of malonyldialdehyde, which is known to be concomitantly released with thromboxane A2 during platelet aggregation. These results suggest that the anti-platelet activity of ilexoside D may not be responsible for prostaglandin synthesis in platelets. |
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