地方性氟骨症硼砂制剂治疗前后骨矿密度和血尿氟变化

１３２例地方性氟骨症病人分别给予硼砂片、复方硼砂片和安慰剂，共６个月。实验前后用单光子吸收法（ＳＰＡ）测定前臂骨矿密度（ＢＭＤ），同时测定血、尿赢（Ｆ－）。与天津市正常人比较，前臂ＢＭＤ女性降低。全部病人血、尿Ｆ－增高。治疗后实验两组前臂ＢＭＤ减低者ＢＭＤ明显增加，血Ｆ－下降，尿Ｆ－无变化。结果表明，氟骨症病人用硼砂制剂治疗后骨代谢异常有所好转。

Changes or bone mineral density,serum and urine fluoride analysis in endemic skeletal fluorosi with borax preparations

patients with endemic skeletal fluorosis were divided into 3 groups: two experimental groups were given borax and borax compound (tablet) respectively, and control group received placebo for a period of 6 months. Forearm BMD decreased in female patients as compared with that of normal,and serum and urine fluoride (F-)increased. After treatment,forearm BMD was found to have a significant rise in patients whose forearm BMD were lower than normal limit Serum F- decreased and urine F- changed insignificantly in two experimental groups. It was suggested that abnormal bone metabolism could be improved with borax preparations in endemic skeletal fluorosis.