砷对小鼠脂质过氧化和抗氧化能力的影响

采用动物实验方法，研究砷对小鼠各组织ＭＤＡ含量，ＳＯＤ活力及全血ＧＳＨ－Ｐｘ活力的影响。结果显示：心脏的中、高剂量组ＭＤＡ水平显著高于对照组和低剂量组，而ＳＯＤ活力则是中、高剂量组显著低于对照组和低剂量组；肝脏的染毒组ＭＤＡ水平均显著高于对照组，而ＳＯＤ活力低剂量组显著高于其它３组，中、高剂量组显著低于对照组和低剂量组；肾脏中仅高剂量组ＭＤＡ水平显著高于对照组，而ＳＯＤ活力各组间无显著差异。全血中的ＧＳＨ－Ｐｘ活力显著下降，并呈剂量－效应关系。表明，砷可促进机体脂质过氧化，抑制抗氧化酶（ＳＯＤ，ＧＳＨ－Ｐｘ）的活力。

The effects of arsenic on lipid peroxidation and the capacity of anti oxidation of mice

Using the method of subchronic animal experiment, the effects of arsenic on the contents of malondialdehyde(MDA)and the activities of superoxide dismutase (SOD)and glutathione peroxidase(GSH Px)blood were observed.Results:MDA levels of heart in middle and high dose group were significantly higher than that in controls and low dose group,but the activities of SOD in middle and high dose group were significantly lower than that in controls and low dose group.MDA levels of liver in all administrated groups were significantly higher than that in controls,but activities of SOD in low dose group significantly higher than others ,and then that in middle and high dose group were significantly lower than controls and low dose group.MDA levels of kidney only in high dose group were significantly higher than that in controls,but activities of SOD in all groups were not significantly different.The activities of GSH Px in blood decreased strikingly and showed a dose effect manner.The results showed that arsenic could induce lipid peroxidation and decrease the capactiy of antioxidase(SOD,GSH Px).