| 尿中麻黄碱类药物的气相色谱检测法 |
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| 引用本文： | 李临,崔建芳,崔凯荣,周屹,王慕邹.尿中麻黄碱类药物的气相色谱检测法[J].药学学报,1991,26(1):67-71. |
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| 作者姓名： | 李临 崔建芳 崔凯荣 周屹 王慕邹 |
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| 作者单位： | 中国医学科学院药物研究所，中国医学科学院药物研究所，国家体委运动医学研究所，国家体委运动医学研究所，中国医学科学院药物研究所 北京 100050，北京 100050，北京 100061，北京 100061，北京 100050 |
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| 摘 要： | 麻黄碱及其类似物有兴奋作用,属体育比赛禁用药。这类化合物的化学结构相似,故有相似的鉴别特征。本文报道了以气相色谱对尿中麻黄碱(ephedrine)、甲基麻黄碱(methylephedrine)、乙基麻黄碱(ethylephedrine)、去甲麻黄碱(norephedrine)及去甲伪麻黄碱(cathine)进行检测,最后以气质联用法进行确证。本法操作简便,灵敏度高,结果可靠。
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| 关 键 词： | 麻黄碱 甲基麻黄碱 乙基麻黄碱 去甲麻黄碱 去甲伪麻黄碱 气相色谱 气质联用 |
| 收稿时间： | 1989-10-30 |
THE IDENTIFICATION OF EPHEDRINE AND ITS ANALOGUES IN URINE BY GAS CHROMATOGRAPHY |
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| L Li,JF Cui,KR Cui,Y Zhou and MZ Wang.THE IDENTIFICATION OF EPHEDRINE AND ITS ANALOGUES IN URINE BY GAS CHROMATOGRAPHY[J].Acta Pharmaceutica Sinica,1991,26(1):67-71. |
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| Authors: | L Li JF Cui KR Cui Y Zhou and MZ Wang |
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| Institution: | Institute of Materia Medicine, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | A sensitive and reliable method of analysis for ephedrine and its analogues was established by using GC and GC-MS. The columns used for both GC and GC-MS were HP-5, and the carrier gas was helium. NPD was used as the detector for GC. The urine sample was extracted with ether and submitted to GC. If positive, it was then submitted to GC-MS to identify its structure. The detection limits for ephedrine and its analogues are lower than 200 ng/ml urine. The recoveries are above 80%. |
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| Keywords: | Ephedrine Methyiephedrine Ethylephedrine Norephedrine Cathine GC GC-MS |
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