阿卡波糖联合二甲双胍治疗2型糖尿病的疗效观察

目的 探讨阿卡波糖联合二甲双胍治疗2型糖尿病的疗效.方法 选择2010年1月～2013年1月在我院内分泌科住院治疗的2型糖尿病患者80例,符合1999年世界卫生组织糖尿病诊断标准,治疗前3个月内无严重心肝肾脏或胰腺并发症及妊娠女性.采用随机数字表将纳入的80例2型糖尿病患者分为观察组和对照组各40例,两组患者均严格控制饮食、加强锻炼,在此基础上对照组予二甲双胍每次0.5g,口服,每日3次,观察组同时联合予阿卡波糖50 mg嚼碎吞服,每日3次,疗程共12周.结果 治疗前对两组患者的FPG、2hPG、HbA1c组间分别比较,差异不显著（P＞0.05）.治疗12周后,两组患者的FPG、2hPG、HbA1c均分别较治疗前明显降低,差异具有显著性（P＜0.05）.且观察组治疗12周后其FPG、2hPG、HbA1c分别较对照组降低更显著,组间比较,差异具有显著性（P＜0.05）.观察组患者显效17例,有效20例,无效3例,对照组显效15例,有效15例,无效10例,观察组患者治疗后的总有效率达92.5%,对照组治疗后的总有效率75.0%,两组治疗后的疗效比较差异具有显著性（P＜0.05）,观察组患者治疗12周后血糖控制的疗效明显优于对照组.治疗12周期间,观察组出现低血糖2例,低血糖发生率达5.0%,对照组治疗期间出现低血糖8例,低血糖发生率达20.0%,观察组低血糖的发生率明显低于对照组（χ2=4.873,P＜0.05）.结论 在严格控制饮食、加强锻炼的基础上应用阿卡波糖联合二甲双胍治疗2型糖尿病疗效确切,可以显著改善患者的血糖水平,降低低血糖发生率,值得广泛推广和应用.

The efficacy of acarbose combined with metformin in treatment of type 2 diabetes

Objective To investigate efficacy of acarbose and metformin in treatment of type 2 diabetes. Methods From January 2010 to January 2013 in our hospital,80 patients with type 2 diabetes were divided into observation group and control group, 40 cases in each group, the patients were strictly controlled diet, exercise, on this basis, each 0.5 mefformin group g, orally, 3 times a day in the observation group chew swallow Acarbose 50 mg, 3 times a day for 12 weeks. Results The two groups of patients before treatment FPG, 2hPG, HbAlc were compared between the two groups, the difference was not significant （P 〉 0.05）. After 12 weeks of treatment, both groups of patients with FPG, 2hPG, HbAlc were significantly lower than before treatment, respectively, and the difference was significant （P 〈 O. 05）. Observation group after 12 weeks of treatment which FPG, 2hPG, HbAlc were reduced more significantly than the control group between the two groups, the difference was significant （P 〈 0.05）. The patients were cured 17 cases, effective in 20 cases, 3 patients in the control group, 15 cases markedly effective in 15 cases, 10 cases were observed in patients after treatment, the total effective rate was 92.5% in the control group after treatment, the total effective 75.0%, compared the efficacy of two groups after treatment between the two groups, the difference was significant （P 〈 0. 05）, observed in patients after 12 weeks of treatment efficacy of glycemic control was significantly better than the control group. During 12 weeks of treatment, the observation group 2 cases of hypoglycemia, hypoglycemia rate of 5% in the control group during the treatment of hypoglycemia in 8 cases, hypoglycemia rate of 20.0% in the observation group, the incidence of hypoglycemia was significantly lower than the control groups, between groups, the difference was significant X2= 4.873, P 〈 0.05）. Conclusion In a strict diet, exercise, based on application of acarbose curative treatment of type 2 diabetes, can significantly improve the patient＇s blood sugar levels and reduce the incidence of hy- poglycemia, should be popularized and applied.