| N-硝基-L-精氨酸对吗啡依赖小鼠催促戒断反应的治疗作用及对吗啡耐受性的影响 |
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| 引用本文： | 赵晶,徐贵丽,苏国丽.N-硝基-L-精氨酸对吗啡依赖小鼠催促戒断反应的治疗作用及对吗啡耐受性的影响[J].解放军药学学报,1999,15(6):9-12. |
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| 作者姓名： | 赵晶 徐贵丽 苏国丽 |
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| 作者单位： | 中国人民解放军成都军区昆明总医院,昆明,650032 |
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| 摘 要： | 目的：研究一氧化氮合酶(NOS)抑制剂N-硝基-L-精氨酸(LNNA)对吗啡依赖小鼠催促戒断反应的治疗作用。方法：采用小鼠戒断模型．观察不同给药途径(ip和ig)．不同剂量的LNNA对吗啡依赖小鼠戒断综合症的治疗效果。结果：NOS抑制剂LNNA可明显延长戒断小鼠跳跃潜伏期，减少小鼠的戒断跳跃反应次数，且抑制其腹泻症状。结论：NOS抑制剂LNNA可延缓吗啡耐受。
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| 关 键 词： | N-硝基-L-精氨酸 吗啡 依赖 耐受 戒断症状 |
EFFECTS OF N-NITRO-L-ARGININE ON MORPHINE TOLERANCE AND ANTAGONIST -PRECIPITATED WITHDRAWL OF MORPHINE-DEPENDENT MICE |
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| Zhao Jing,Xu Guili,Su Guoli.EFFECTS OF N-NITRO-L-ARGININE ON MORPHINE TOLERANCE AND ANTAGONIST -PRECIPITATED WITHDRAWL OF MORPHINE-DEPENDENT MICE[J].Pharmaceutical Journal of Chinese People's Liberation Army,1999,15(6):9-12. |
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| Authors: | Zhao Jing Xu Guili Su Guoli |
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| Abstract: | AIM To investigate the effects of N-Nitro-L-Arginine(LNNA) on antagonist-precipitated withdrawl of morphine-dependent mice.METHODS The inhibitory effects of different dosages of LNNA by ig and ip administration on abstinent syndrome induced by naloxone in morphine-dependent mice were observed,and tolerance of pain was determined by hot plate method.RESULTS LNNA prolongated tolerance of analgesic effect, decreased jump and inhibited diarrea.CONCLUSION LNNA controls the abstinence syndromes of morphine addicted mice, prolongates morphine tolerance and shows less toxicity. |
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| Keywords: | N G-nitro-L-arginine Morphine Dependence Tolerance Antagonist-precipitated withdrawl |
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