长春瑞滨联合顺铂治疗非小细胞肺癌

目的：观察长春瑞滨（诺维本，ＮＶＢ）联合顺铂（ＤＤＰ）治疗非小细胞肺癌的疗效。方法：６０例患者分别用ＮＰ（ＮＶＢ加ＤＤＰ）方案和ＭＮＰ「丝裂霉素（ＭＭＣ）联合ＮＶＢ与ＤＤＰ」方案治疗。结果：ＮＰ和ＭＮＰ组有效率分别为４２．９％（１２／２８）和４６．９％（１５／３２），两者无显著差异（Ｐ〉０．０５）。分析诸多因素对疗效的影响发现，病期早较病期晚疗效好，鳞癌比腺癌疗效好。骨髓抑制为限制性毒性，白细胞下

Treatment of non-small-cell lung cancer with vinorelbine plus cisplatin

Purpose:To observe the therapeutic effects of vinorelbine (NVB) plus cisplatin (DDP) (NP regimen) for the treatment of non small cell lung cancer (NSCLC). Methods:60 cases were treated with NP (NVB plus DDP) or MNP[mitomycin (MMC) plus NVB and DDP] regimen. Results:Response rates were 42.9% (12/28) and 46.9%(15/32),respectively for these two regimens. No statistical difference was noted in responses between these two groups (P>0 05). Neutropenia was the dose limiting toxicity and occurred in 82.1% of cases in the NP regimen and 87.5% in the MNP regimen (P>0 05). No other serious side reactions occurred in either groups. Conclusions:The NP regimen can obtain results just as good as with the MNP regimen in the treatment of NSCLC.