| 小体积肝动物模型的CT灌注成像研究 |
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| 引用本文： | 庄治国,许建荣,钱黎俊,池嘉昌,夏强,张明. 小体积肝动物模型的CT灌注成像研究[J]. 临床放射学杂志, 2011, 30(7) |
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| 作者姓名： | 庄治国 许建荣 钱黎俊 池嘉昌 夏强 张明 |
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| 作者单位： | 1. 上海交通大学医学院附属仁济医院放射科,200127
2. 上海交通大学医学院附属仁济医院肝脏移植科,200127 |
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| 基金项目： | 上海市重点学科建设资助项目(S30203); 上海交通大学医学院重点学科资助项目(第三期) |
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| 摘 要： | 目的利用CT灌注成像(CTPI)技术观察小体积(SFS)肝动物模型的血流动力学变化以及降低门静脉灌注量(PVP)手术对其影响。材料与方法20只新西兰白兔分为两组,对照组(n=10)仅行扩大肝切除术建立SFS肝模型,调节组(n=10)行扩大肝切除术后加脾切除术以降低PVP,运用CTPI在术前术后分别测量两组动物的灌注参数,分析和比较灌注值的变化和预后。结果调节组术后7天生存率为40.0%,优于对照组的0.0%(P=0.020)。对照组术后PVP增加率为(193.7±55.1)%,与切除肝质量与体重比值(RLBWR)之间存在弱相关性(r=0.465,P=0.033),调节组术后PVP增加率为(101.4±32.5)%,与RLBWR之间无明显相关性(r=0.167,P=0.644)。术后PVP与血清谷草氨酸转氨酶、丙氨酸转氨酶和总胆红素均呈明显正相关(P值均<0.05)。结论运用CTPI可观察SFS肝的血流动力学变化特点和脾切除术对血流灌注的影响,降低PVP能改善SFS肝的预后。
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| 关 键 词： | 体层摄影术 X线计算机 小体积肝 灌注 血流动力学 |
CT Perfusion Imaging Study of Small-for-size Liver Animal Models |
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| ZHUANG Zhiguo,XU Jianrong,QIAN Lijun,et al.. CT Perfusion Imaging Study of Small-for-size Liver Animal Models[J]. Journal of Clinical Radiology, 2011, 30(7) |
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| Authors: | ZHUANG Zhiguo XU Jianrong QIAN Lijun et al. |
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| Affiliation: | ZHUANG Zhiguo,XU Jianrong,QIAN Lijun,et al. Department of Radiology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,P.R.China |
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| Abstract: | Objective To observe the hemodynamic changes in small-for-size(SFS) liver models using CT perfusion imaging(CTPI),and to investigate the effects of reducing the portal venous perfusion(PVP) by surgery on SFS livers.Materials and Methods 20 New Zealand white rabbits were divided into two groups:one group in which extended hepatectomy was carried out alone(control group,n=10) to make SFS liver models,and another group in which extended hepatectomy was carried out and then splenectomy was performed to reduce p... |
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| Keywords: | Tomography X-ray computed Small-for-size liver Perfusion Hemodynamics |
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