| 磁共振扩散加权成像预测、监测直肠癌放化疗效果的价值 |
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| 引用本文： | 赵海,高明勇,谭湘萍,雍防,卢瑞梁,刘建萍.磁共振扩散加权成像预测、监测直肠癌放化疗效果的价值[J].临床放射学杂志,2011,30(6). |
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| 作者姓名： | 赵海 高明勇 谭湘萍 雍防 卢瑞梁 刘建萍 |
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| 作者单位： | 中山大学附属佛山医院磁共振室,广东省佛山市,528000 |
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| 摘 要： | 目的探讨MR扩散加权成像(diffusion-weighted imaging,DWI)在预测、监测直肠癌放、化疗效果中的应用价值。资料与方法动态监测15例行放、化疗的直肠癌患者,于放化疗前、放化疗结束和放化疗后4~5周行3次常规MRI及DWI。测量直肠癌的长度、肿瘤侵犯直肠壁厚度和表观扩散系数(apparent diffusion coefficient,ADC)值在放化疗前、后各时间点的变化,并分别进行比较;依据实体瘤疗效评价标准(RECIST)分组,比较各组在放化疗前ADC值之间的差异。结果直肠癌放化疗结束时,肿瘤侵犯肠壁的厚度较放化疗前差异有统计学意义(0.010.05);而对于放化疗结束与放化疗后4~5周,三者的变化差异均无统计学意义。放化疗前部分缓解(PR)与病灶稳定(SD)组之间的ADC值差异无统计学意义(P=0.222>0.05)。结论 DWI可优先、准确评价直肠癌放化疗的疗效相对于肿瘤形态学变化;而放化疗前ADC值对于预测直肠癌放化疗的疗效无明显意义...
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| 关 键 词： | 直肠癌 扩散加权成像 表观扩散系数 放化疗 实体瘤疗效评价标准 |
The Clinical Value of DWI in Predicting and Monitoring Radiochemotherapy Effect in Rectal Cancer |
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| ZHAO Hai,GAO Mingyong,TAN Xiangping,et al..The Clinical Value of DWI in Predicting and Monitoring Radiochemotherapy Effect in Rectal Cancer[J].Journal of Clinical Radiology,2011,30(6). |
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| Authors: | ZHAO Hai GAO Mingyong TAN Xiangping |
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| Institution: | ZHAO Hai,GAO Mingyong,TAN Xiangping,et al.MR Section,the Affiliated Foshan Hospital of Sun Yat-sen Univercity,Foshan,Guangdong Province 528000,P.R.China |
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| Abstract: | Objective To investigate the clinical value of diffusion weighted imaging(DWI) in predicting and monitoring radiochemotherapy effect in rectal cancer.Materials and Methods Fifteen patients with rectal cancer underwent conventional MRI and DWI examination at 3 time points: before radiochemotherapy(1st time point),radiochemotherapy completed(2nd time point),4-5 weeks after radiochemotherapy(3rd time point).The parameters,including the length of tumors,the thickness of rectal wall and apparent diffusion coeffi... |
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| Keywords: | Rectal cancer Diffusion-weighted imaging Apparent diffusion coefficient Radiochemotherapy Response evaluation criteria in solid tomors |
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