| c－Ha－ras反义寡聚脱氧核苷酸对人膀胱癌细胞生长增殖的抑制作用 |
| |
| 引用本文： | 李鸣,于茂生,靳风烁.c－Ha－ras反义寡聚脱氧核苷酸对人膀胱癌细胞生长增殖的抑制作用[J].中华泌尿外科杂志,1995(10). |
| |
| 作者姓名： | 李鸣 于茂生 靳风烁 |
| |
| 作者单位： | 解放军第三医院泌尿外科，第四军医大学西京医院泌尿外科，第三军医大学大坪医院泌尿外科 |
| |
| 摘 要： | 应用人工合成的ｃ－Ｈａ－ｒａｓ反义寡聚脱氧核苷酸（ＡＳＯ－ｒ）对人膀胱癌细胞Ｔ２４进行作用。结果显示：ＡＳＯ－ｒ能明显抑制癌细胞中ｒａｓＰ２１的表达，并能引起Ｔ２４中ｒａｓＰ２１的表达及Ｔ２４细胞生长增殖的抑制，且不同浓度的ＡＳＯ－ｒ其抑制率不同。结果表明：ＡＳＯ－ｒ能够抑制膀胱癌细胞株Ｔ２４中ｒａｓＰ２１的表达及Ｔ２４细胞的生长增殖，抑制作用大小与ＡＳＯ－ｒ的浓度有关。
|
| 关 键 词： | 膀胱肿瘤，癌，基因 |
Inhibitory effects of c-Ha-ras antisence oligodeoxynucleotide on the human bladder cancer cell line |
| |
| Li ming,Yu Maosheng,Jin Fengshuo.Inhibitory effects of c-Ha-ras antisence oligodeoxynucleotide on the human bladder cancer cell line[J].Chinese Journal of Urology,1995(10). |
| |
| Authors: | Li ming Yu Maosheng Jin Fengshuo |
| |
| Abstract: | Inhibitory effects of c-Ha-ras antisence oligodeoxynuclotide on the expression of ras p21 and the growth of human bladder cancer cells were investigated.Synthetic 15-mer directed at the region of the translational inition site of c-Ha-ras proto-oncogene(ASO-r)greatly inhibited the proliferation and DNA synthesis of T24 cells.These studies demonstrated that ASO-r had an inhibitory effect on the expression of c-Ha-ras protooncogene and might control the growth of human bladder cancer cells. |
| |
| Keywords: | Bladder neoplasms Carcinoma Genes |
| 本文献已被 CNKI 等数据库收录！ |
