电针不同穴位对单眼视神经离断家兔FVEP的影响

目的:探讨针灸影响视觉系统的效应及其机理,明确视神经中之离中纤维在针刺影响视觉功能过程中的作用.方法:24只白兔随机分为"合谷"组与"太溪"组,每组12只,制作单眼视神经离断家兔模型,切断视网膜与中枢的联系,但不损伤视网膜血循环,观察电针对双眼闪光视觉诱发电位(FVEP)的影响.结果:在切断视神经时下行调制视网膜的离中纤维也被切断,术眼FVEP熄灭.电针"合谷"与"太溪"穴各时期对FVEP之N1、P1、N2各波峰潜时、振幅均有较强的抑制作用,表现为峰潜时延长,振幅明显降低,且这种抑制作用具有穴位的差异性.结论:离中纤维在电针影响家兔闪光视网膜电图(FERG)及FVEP的过程中起到一定的作用,但针刺对FERG影响的主要途径不是通过中枢的下行性抑制,而是通过影响离中纤维在有限程度上对视网膜产生的影响.

Effects of electroacupuncture at different acupoints on FVEP in the rabbit with separated monocular optic nerve

OBJECTIVE: To study the effect of acupuncture and moxibustion on the visual system and the mechanism. METHODS: Twenty-four rabbits were randomly divided into a "Hegu" (Ll 4) group and a "Taixi" (KI 3) group, 12 rabbits in each group. The rabbit model with separated monocular optic nerve was developed, cutting the link between the retina with the center, but do not injure the blood circulation in the retina. The effect of electroacupuncture on flicker vision evoked potential (FVEP) was investigated. RESULTS: When the optic nerve was cut off, the distal fibers of descending regulating the retina were cut off, the FVEP of the operative eye extinguished. Elctroacupuncture at "Hegu" (LI 4) and "Taixi" (KI 3) at various stages have stronger inhibiting action on the latent time and amplitudes of N1, P1, N2 of FVEP, marked by prolongation of the latent time of peak, and obvious decrease of the amplitude. And this inhibiting action has difference of acupoints. CONCLUSION: The distal fiber plays a certain role in the process of electroacupuncture influencing flicker electroretinogram (FERG) and FVEP, but the effect of acupuncture on FERG is induced through the distal fibers to influence the retina in a limited extent, but not through the central descending inhibition.