生殖器疱疹患者尿道和宫颈HSV感染的研究

目的：了解生殖器疱疹（GH）患者伴发宫颈和男性尿道单纯疱疹病毒（HSV）感染情况，进一步探讨HSV和非淋菌性尿道炎／官颈炎（NGU）的关系。方法：用HSV聚合酶链反应（PCR）方法检测了56例GH患者的宫颈和男性尿道拭子标本。结果：56例患者中HSV PCR检测阳性共5例，阳性率为8．93％（5／56）。20例女性生殖器疱疹患者宫颈HSV PCR检测阳性率为25．0％（5／20）；36例男性GH患者尿道HSV PCR检测结果均为阴性。结论：生殖器疱疹患者伴发女性宫颈HSV感染更为常见，而伴发男性尿道HSV感染相对少见。HSV感染可能是非淋菌性尿道炎／宫颈炎的一个致病因子，在女性宫颈炎的发病中可能更有意义。

The detection of HSV infection in cervix and male urethra in genital herpes patients

Objective: To identify the frequency of cervical and male urethral HSV infection in genital herpes patients, and to investigate the possible pathogenic role of HSV in nongonococcal urethritis/cervicitis. Methods: Polymerase chain reaction (PCR) was employed to detect HSV DNA in the cervical and male urethral specimens obtained from 56 genital herpes patients. Results: HSV DNA was detected in 5 patients accounting for 8.93% (5/65). All of the above 5 cases were female, and the positivity rate in female patients was 25%(5/25). All the 36 male patients showed negative results in the HSV PCR test. Conclusion: In genital herpes patients, the complicated female cervical HSV infection is more common than male urethral HSV infection. HSV can be a causative agent in nongonococcal urethritis/cervicitis, and its role may be more significant in women than in men.