Inhibition of ectopic glioma tumor growth by a potent ferrocenyl drug loaded into stealth lipid nanocapsules |
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| Affiliation: | 1. LUNAM Université – Micro et Nanomédecines Biomimétiques, Angers, France;2. Inserm U1066, IBS-CHU, Angers, France;3. Département de Neurochirurgie – CHU, Angers, France;4. Département de Pathologie Cellulaire et Tissulaire – CHU, Angers, France;5. CNRS, UMR 7576, ENSCP, Paris, France;6. Inserm U908, Université Lille 1, Villeneuve d''Ascq, France;1. School of Pharmacy, University of Waterloo, Waterloo, ON, Canada;2. School of Optometry, University of Waterloo, Waterloo, ON, Canada;3. Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada;4. University Health Network, Division of Visual Science, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada;1. Nanomedicine and Molecular Imaging Group, Department of Clinical Medicine, Institute for Molecular Medicine, St James’ Hospital, Dublin 8, Ireland;2. Nanomaterials Research Group, School of Chemistry, Trinity College Dublin, Dublin 2, Ireland;3. Nanomedicine and Molecular Imaging Group, Department of Clinical Medicine, Institute for Molecular Medicine, St James’ Hospital, Trinity College Dublin, Dublin, Ireland;4. Centre for Research on Adaptive Nanostructure and Nanodevices (CRANN), Trinity College Dublin, Ireland;1. Department of Food Science and Technology, University of Georgia, Athens, GA, USA;2. Science and Technology on Plasma Physics Laboratory, Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang, China;3. Department of Physics and Astronomy, University of Georgia, Athens, GA, USA;4. Department of Microbiology and Immunology, Emory University School of Medicine, and Veterans Affair Medical Center, Atlanta, GA, USA;5. Nanoscale Science and Engineering Center, University of Georgia, Athens, GA, USA |
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| Abstract: | In this work, a novel ferrocenyl complex (ansa-FcdiOH) was assessed for brain tumor therapy through stealth lipid nanocapsules (LNCs). Stealth LNCs, prepared according to a one-step process, showed rapid uptake by cancer cells and extended blood circulation time. The ferrocenyl complex was successfully encapsulated into these LNCs measuring 40 nm with a high loading capacity (6.4%). In vitro studies showed a potent anticancer effect of ansa-FcdiOH on 9L cells with a low IC50 value (0.1 μM) associated with an oxidative stress and a dose-dependent alteration of the cell cycle. Repeated intravenous injections of stealth ansa-FcdiOH LNCs in ectopic glioma bearing rats induced a significant tumor growth inhibition, supported by a reduced number of proliferative cells in tumors compared to control group. Additionally, no liver damage was observed in treated animals. These results indicated that stealth ansa-FcdiOH LNCs might be considered as a potential new approach for cancer chemotherapy.From the Clinical EditorIn this study, a novel ferrocenyl complex was assessed for brain tumor therapy through stealth lipid nanocapsules, demonstrating no liver damage, and superior tumor volume reduction compared to saline and stealth lipid nanocapsules alone in an ectopic glioma model. |
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