Influence of eating behaviors on short-term weight loss by orlistat and anorectic agent |
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| Affiliation: | 1. 110 Chandlee Laboratory, Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA;2. 260A Bevier Hall, Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61802, USA;3. 102 Ackerman Hall, Department of Food and Nutrition, Indiana University of Pennsylvania, Indiana, PA 15705, USA;4. 1 UNF Drive, Nutrition and Dietetics, Building 39, University of North Florida, Jacksonville, FL 32224, USA;1. Dept. of Psychiatry, All India Institute of Medical Science, Jodhpur, India;2. Dept. of Psychiatry, All India Institute of Medical Science, New Delhi, India;1. “Studi Cognitivi” Post-graduate Cognitive Psychotherapy School Milano, Italy;2. GNOSIS non-profit research group, Cuneo, Italy;3. Eating Disorders and Obesity Surgery, ULSS 13, Mirano-Dolo, Venice, Italy;4. Human Nutrition and Eating Disorders Research Center, Department of Public Health, Neuroscience, Experimental and Forensic Medicine, University of Pavia, Italy |
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| Abstract: | Little data exists concerning whether eating behaviors determine the response to orlistat treatment, especially with added anorectic agents. This study was a sub-investigation of a 12-week randomized controlled trial for the additive effect of orlistat on sibutramine treatment. The analysis presented here was restricted to 98 women who had fulfilled the protocol. The Dutch eating behavior questionnaire and three-factor eating questionnaire were used to assess eating behaviors. Scores of emotional eating, external eating, disinhibition and hunger are significantly interrelated. Using multiple logistic analysis with adjustment for potential confounders, such as age, initial BMI and the other 2 eating behavior scores, traits of emotional eating (OR 0.30, 95% CI 0.13–0.74) and disinhibition (OR 0.61, 95% CI 0.40–0.82) have a significant influence on prediction for additional 5% weight loss in the treatment with orlistat and sibutramine. Subjects with less vulnerability to emotional cues had significantly more weight loss with orlistat treatment and anorectic agents. |
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