术前血清甲状腺球蛋白检测对甲状腺乳头状癌颈部淋巴结转移的预测价值分析

目的 探讨术前血清甲状腺球蛋白(Preoperative serum thyroglobulin,PS-Tg)与甲状腺乳头状癌(Papillary carcinoma of thyroid,PTC)淋巴结转移(Lymph node metastasis,LNM)的关系。方法 本研究纳入2021年10月—2022年10月行甲状腺切除术并经术后病理证实的PTC患者,并收集其临床及病理资料283份。单因素、多因素logistic回归分析PS-Tg与PTC LNM的关系,绘制列线图将两者关系量化,通过ROC曲线确定最佳截断值。结果 PTC合并LNM组PS-Tg水平高于单纯PTC组(P＜0.05),单因素与多因素logistic回归分析发现PS-Tg水平升高可能是PTC发生LNM的独立危险因素,且PS-Tg水平升高可解释约15%的PTC LNM风险。结论 PS-Tg水平升高可能是PTC患者颈部LNM的危险因素,对术前LNM诊断有一定的预测价值。

Analysis for predictive value of preoperative serum thyroglobulin detection in cervical lymph node metastasis of thyroid papillary carcinoma

Objective The Objective of this study was to investigate the relationship between preoperative serum thyroglobulin(PS-Tg)and lymph node metastasis(LNM)in papillary thyroid carcinoma(PTC). Methods This study included 283 clinical and pathological data of PTC patients who underwent thyroidectomy from October 2021 to September 2022 and were confirmed by postoperative pathology.The relationship between PS-Tg and PTC LNM was analyzed by univariable and multivariable logistic regression,the nomogram was used to quantify the relationship between them,and the optimal cut-off value was determined by receiver operating characteristic(ROC)curves. Results The level of PS-Tg in the PTC combined with LNM group was higher than that in the pure PTC group(P＜0.05).Univariable and multivariable logistic regression analyses showed that elevated PS-Tg level might be an independent risk factor for LNM of PTC,and the increase of PS-Tg level could explain approximately 15% of the risk of LNM in PTC. Conclusion Elevated PS-Tg level may be a risk factor for cervical LNM in PTC patients,and it has a certain predictive value for preoperative LNM diagnosis.