Exploring the Role of Muscle Mass,Obesity, and Age in the Relationship Between Muscle Quality and Physical Function |
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| Institution: | 1. Département de Biologie, Université du Québec À Montréal, Montréal, Canada;2. Groupe de Recherche en Activité Physique Adaptée, Université du Québec À Montréal, Montréal, Canada;3. Département de Kinanthropologie, Université du Québec À Montréal, Montréal, Canada;4. Centre de Recherche de l''Institut Universitaire de Gériatrie de Montréal, Montréal, Canada;5. Service de Médecine Interne et de Gérontologie Clinique, Gérontopôle de Toulouse, Hôpital La Grave-Casselardit, Toulouse, France;6. Unité Inserm 1027, Faculté de médecine de Toulouse, Toulouse, France;1. Post-Graduate Program in Gerontology, Catholic University of Brasília, Brasília, Brazil;2. Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil;1. Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif;2. Division of Geriatrics, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif;1. Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore;2. Department of Rehabilitation Medicine, Tan Tock Seng Hospital, Singapore;3. Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore;1. Department of Public Health Sciences, University of Rochester, Rochester, NY;2. Canandaigua Veterans'' Administration Medical Center, Canandaigua, NY;3. Center for Gerontology and Health Care Research, School of Public Health, Brown University, Providence, RI |
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| Abstract: | BackgroundDivergent conclusions emerge from the literature regarding the relationship between muscle quality (defined as muscle strength per unit of muscle mass) and physical function. These contrasted results may be due to the influence of factors such as age, obesity, and muscle mass itself. Consequently, the aim of the present study was to explore the role of these factors in the relationship between muscle quality (MQ) and physical function.MethodsData are from 312 individuals (97 men and 215 women) aged 50 years and older. Body composition (dual energy X-ray absorptiometry) and knee extension strength of the right leg (1 repetition maximum) were assessed. Appendicular lean body mass index (AppLBMI) and MQ (knee extension strength /right leg lean mass) were calculated. A composite score of physical function was created based on the timed up-and-go, alternate step, sit-to-stand, and balance tests.ResultsMQ was significantly associated with physical function when AppLBMI (β = 0.179; P = .004) and body mass index (BMI) (β = 0.178; P = .003), but not age (β = 0.065; P = .26), were included in regression analysis. AppLBMI (β = 0.221; P < .001), BMI (β = 0.234; P < .001), and age (β = 0.134; P = .018) significantly interacted with MQ to determine physical function.ConclusionsOur results show that muscle mass, obesity, and age influence the relationship between MQ and physical function, suggesting that these factors should be taken into account when interpreting MQ. Even so, higher levels of MQ were associated with higher physical function scores. Nutritional and physical activity interventions may be designed in this regard. |
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| Keywords: | Appendicular lean body mass index body mass index muscle quality functional capacity aging |
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