Promoting effect of <Emphasis Type="Italic">o</Emphasis>-aminoazotoluene on hepatocarcinogenesis is accompanied by the increase in inflammatory and proliferative processes in liver tissue and decrease in the concentration of free thyroxin in the blood |
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| Authors: | N V Baginskaya S I Il’nitskaya E V Nikitenko V I Kaledin |
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| Institution: | (1) Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk;(2) Military Hospital No. 333, Russian Ministry of Defense, Novosibirsk |
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| Abstract: | o-Aminoazotoluene in noncarcinogenic doses promoted the development of liver tumors in female ICR mice induced by administration
of diethylnitrosamine during early ontogeny. Severe inflammatory infiltration and proliferation of oval cells were found in
liver tissue of these animals. The concentration of free thyroxin decreased in the blood. Our results supplement published
data that promoters of hepatocarcinogenesis inhibit thyroid function.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 12, pp. 672–675, December, 2007 |
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| Keywords: | hepatocarcinogenesis diethylnitrosamine o-aminoazotoluene promotion thyroid hormones |
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