晚发性抑郁患者情绪调节机制的ERPs研究

目的采用事件相关电位探讨晚发性抑郁患者情绪调节障碍的神经生理机制。方法被试者包括16例晚发性抑郁患者（发病年龄≥60岁）与16名健康老年人。采用Go／Nogo实验范式，要求被试者对刺激序列中双个三角形进行按键反应（Go），单个三角形不反应（Nogo）。记录32导脑电。结果健康老年人中，Nogo刺激产生了明显的额中央区分布的N2Nogo和P3Nogo；与对照组相比，病例组的N2Nogo。波幅明显增高，而P3Nogo波幅显著降低，两者潜伏期无显著差异。结论晚发抑郁患者存在情绪调节障碍，其电生理学指标为N2Nogo明显增高和P3Nogo的显著降低，为晚发性抑郁的诊断和治疗提供了一定的客观评价指标。

Emotion Regulation Deficit in Patients of Late-onset Depression Revealed by ERP Study

Objective To investigate the electrophysiological evidence of emotion regulation deficit in patients of late-onset depression(LOD).Method Sixteen patients with late-onset depression and 16 aged healthy volunteers received a Go/Nogo task.The stimuli were single or double triangular figures,and appeared pseudorandomly with equal probability.The subjects were instructed to press a button as quickly and correctly as possible when the double triangular figure was presented(i.e.,Go),but make no response to the single triangular figure(i.e.,Nogo).Result N2_(Nogo) and P3_(Nogo)(elicited) by Nogo stimuli were found as compared to Go stimuli in both two groups,which were significant over the fronto-central area of the scalp.Larger N2_(Nogo) and smaller P3_(Nogo) were observed in patients with depression than that in healthy subjects.No significant differences were found between the latencies of N2_(Nogo) and P3_(Nogo) of the two groups.Conclusion These findings suggest that as shown by the stronger N2_(Nogo) and reduced P3_(Nogo),emotional regulation deficit is obvious in patients with late onset depression patients.It provides an objective index for the diagnosis and treatment of LOD.