| 神经节苷脂-1对大鼠重型颅脑创伤后学习记忆功能的影响 |
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| 引用本文： | 武英,刘清军.神经节苷脂-1对大鼠重型颅脑创伤后学习记忆功能的影响[J].华北煤炭医学院学报,2004,6(5):563-564. |
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| 作者姓名： | 武英 刘清军 |
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| 作者单位： | 1. 华北煤炭医学院预防医学系,河北,唐山,063000
2. 华北煤炭医学院附属医院,河北,唐山,063000 |
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| 摘 要： | ①目的:探讨神经节苷脂-1(GM01)对大鼠重型颅脑创伤后学习记忆功能的影响。②方法:采用Marmarou法建立大鼠重型闭合性颅脑创伤模型，将成年Wistar大鼠48只随机分为脑创伤组、GM-1治疗组、假手术组与正常对照组，每组12只。GM-1治疗组致伤后，给予腹腔注射GM-1；脑创伤组、假手术组及正常对照组在相同时间腹腔注射等量的生理盐水。均于伤后7天进行水迷宫测试。③结果:GM-1组较创伤组水迷宫测试的潜伏期明显缩短。④结论:GM-1可有效改善大鼠重型颅脑创伤后学习记忆障碍。
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| 关 键 词： | 颅脑创伤 神经节苷脂-1 水迷宫试验 大鼠 |
| 文章编号： | 1008-6633(2004)05-0563-02 |
| 修稿时间： | 2004年5月10日 |
The effect of GM-1 on cognitive function after severe traumatic brain injury in rats |
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| WU Ying,LIU Qingjun.The effect of GM-1 on cognitive function after severe traumatic brain injury in rats[J].Journal of North China Coal Medical College,2004,6(5):563-564. |
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| Authors: | WU Ying LIU Qingjun |
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| Abstract: | Objective To investigate the effect of GM-1 on cognitive function after severe traumatic brain injury in rats. Methods The model of severe closed traumatic brain injury(TBI) was established according to the method created by Marmarou. 48 Wistar rats were divided randomly into TBI group, GM-1 treating group, fake operation group and the normal group, each group has 12 rats. The GM-1 treating group after injury were treated with GM-1 in peritoneum; TBI group, the fake operation group and the normal group were treated with Saline for comparison. 7 days after TBI, their cognitive dysfuction was evaluated using the Morris water maze (MWM). Results GM-1 can shorten obviously the delitescence of Morris water maze tests. Conclusions GM-1 may effectively improve cognitive dyfunction after TBI. |
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| Keywords: | Severe closed traumatic brain injury GM-1 Morris water Maze Rats |
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