精神分裂症患者事件相关电位P300亚成分治疗前后比较

目的 观察精神分裂症患者急性期事件相关电位P300亚成分的变异及其恢复期的变化。方法 应用美国Nicolet Bravo大脑电生理仪，检测17例精神分裂症患者及18例健康对照的P300亚成分，并观察精神分裂症患者用药治疗4周后P300的变化。结果 与正常对照相比在四个记录区（C3、C4、Cz、Pz），靶波幅P3a、P3b均显著下降，P3a、P3b潜伏期在四个记录区均未见明显差异。患者用药治疗4周后尽管临床症状明显改善，但与用药前比较P300波幅、潜伏期均无显著差异。结论 精神分裂症患者存在B00亚成分各脑区的广泛变异。波幅降低不是抗精神病药物的影响，在发病初期就已存在，可能是一稳定的素质标记。

Follow-up study of P300 subcomponents of schizophrenic

Objective To investigate the variation of event-related potentials P_(300) subcomponents of schizophrenic patients in episodic and remitted state. Methods P_ 300 subcomponents was recorded with an USA Nicolet Brovo instrument from17 schizophrenic patients before and after 4 weeks under risperidone. Results P_ 300 subcomponents amplitude was significantly decreased in episodic patients at four electrode(C_3,C_4,C_z,P_z), compared with normal control.No there were significant differences for P_ 300 subcomponents latency.For the whole sample subcomponent amplitudes did not change following 4 weeks despite clinical improvement. Conclusion It suggests that the variation of P_(300) subcomponent amplitude is trait marker of schizophrenia.