Triterpene Saponins from the Roots of Achyranthes bidentata |
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| Authors: | A. Marouf S. Desbene T.C. Khanh H. Wagner B. Chauffert |
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| Affiliation: | 1. Departement de Biologie, Faculte des Sciences, Universite d'Oran, Algeria;2. Department of Chemistry, Hanoi College of Pharmacy, University of Hanoi, Vietnam;3. Institut fur Pharmazeutische Biologie der Universitat Munchen, Munchen, Germany;4. Unite INSERM 517 "Mort Cellulaire et Cancer", Faculte de Medecine, Universite de Bourgogne, Dijon, France;5. Laboratoire de Pharmacognosie, Unite MIB, Faculte de Pharmacie, Universite de Bourgogne, Dijon, France |
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| Abstract: | Three saponins, oleanolic acid-28- O -ß-D-glucopyranoside (1), chikusetsusaponin V (2), and 3- O -ß-D-glucopyranosyl-oleanolic acid-28- O -ß-D-glucopyranoside (3) were isolated from the roots of Achyranthes bidentata Blume (Amaranthaceae). No activity was shown in the granulocyte phagocytosis test nor in the test of the potentiation of the cytotoxicity of cisplatin in human colon cancer cells. This is the first report of compounds 1, 2 and 3 isolated from Achyranthes species. Furthermore, the NMR data of 2 completed the partially published data. |
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| Keywords: | Ashwagandha churna delayed-type hypersensitivity (DTH) neutrophil adhesion |
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