Pharmacological Studies of Mentha longifolia Phenolic Extracts. II. Hepatoprotective Activity |
| |
| Authors: | Neda Mimica-Dukic Mira Popovic Vida Jakovljevic Anna Szabo Olga Gašic |
| |
| Affiliation: | 1. Institute of Chemistry, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Trg Dositeja Obradovica 3, Yugoslavia;2. Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmocology, University of Novi Sad, 21000 Novi Sad, Yugoslavia |
| |
| Abstract: | The effects of Mentha longifolia crude ethanolic extract (F 1), rich in luteolin glycosides (F 2), apigenin glycosides (F 3) and phenolic acids (F 4), were studied on CCl 4 -induced liver injury in mice. Administration of CCl 4 -induced significant impairment in hepatic antioxidant status, decreasing the glutathione content and superoxide dismutase activity, and stimulating lipid peroxidation. Pretreatment with Mentha longifolia extracts significantly improved hepatic antioxidant status in mice, which was most pronounced in the reduction of CCl 4 -mediated lipid peroxidation. In addition, in pretreated animals, an increase in hepatic glutathione and superoxide dismutase activity, as well as a decrease of cytochrome P450, was found. |
| |
| Keywords: | Angiopteris evecta antioxidants Citrus hystrix free radical scavenging activity Laurentia longiflora Nelumbo nucifera Piper sarmentosum Portulaca oleracea Stachytarphera indica |
|
|
