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Isoarenarol,A New Protein Kinase Inhibitor from the Marine Sponge Dysidea arenaria |
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| Authors: | Hye-Dong Yoo Dan Leung Jasbinder Sanghara Darren Daley Rob Soest Raymond J Andersen |
| Institution: | 1. Departments of Chemistry and Oceanography-Earth and Ocean Sciences, University of British Columbia, Vancouver, Canada;2. Pharmaceuticals Inc., Vancouver, British Columbia;3. Department of Coelenterates and Porifera, Institute for Systematics and Population Biology, (Zoologisch Museum) University of Amsterdam, Amsterdam, The Netherlands |
| Abstract: | The novel sesquiterpene hydroquinone isoarenarol (1) and the known compound arenarol (2) were isolated from extracts of the marine sponge Dysidea arenaria Bergquist as part of a search for new protein kinase inhibitors. Both 1 and 2 showed potent and selective protein kinase inhibition in vitro. |
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