胱抑素C与多发性肌炎和(或)皮肌炎患者左室舒张功能相关性及应用评价

目的分析胱抑素C与多发性肌炎(PM)和(或)皮肌炎(DM)患者左室舒张功能不全的关系,并评价其临床应用价值。方法收治126例PM和(或)DM患者,免疫比浊法测定血清胱抑素C水平,心脏彩色多普勒超声评价左心功能,通过logistic回归分析胱抑素C与患者左室舒张功能间的关系,ROC曲线评价胱抑素C对左室舒张功能不全的诊断价值。结果相对于PM和(或)DM左室舒张功能正常者,并发左室舒张功能不全者年龄偏大、胱抑素C水平升高(P<0.01),抗Jo-1抗体阳性率低(P<0.01)。Logistic回归发现胱抑素C与左室舒张功能不全密切相关(P<0.05),ROC曲线显示胱抑素C的曲线下面积0.703,诊断PM和(或)DM左室舒张功能不全的灵敏度67%,特异度68%,准确度67%。结论胱抑素C与PM和(或)DM患者左室舒张功能不全相关,胱抑素C水平越高,左室舒张功能不全发生可能性越大,具有一定的诊断价值。

Correlation and application evaluation of cystatin C with left ventricular diastolic function in patients with polymyositis and/or dermatomyositis

AIM To analyze the relationship between cystatin C and left ventricular diastolic dysfunction in patients with polymyositis (PM) and/or dermatomyositis (DM), and to evaluate its clinical value. METHODS One hundred and twenty-six patients with PM and/or DM were included. The serum cystatin C level was measured by immunoturbidimetry. The left heart function was evaluated by color Doppler echocardiography. The relationship. between cystatin C and left heart function was analyzed by logistic regression. And ROC curve was used to evaluate the diagnostic value of cystatin C for left ventricular dysfunction. RESULTS Compared with those with normal left ventricular diastolic function in PM and/or DM, those with left ventricular diastolic dysfunction were older, cystatin C level was higher (P<0.01), and the positive rate of anti Jo-1 antibody was lower (P<0.01). Logistic regression further shows that cystatin C is closely related to left ventricular diastolic dysfunction (P<0.05). ROC curve showed that the area under the curve of cystatin C was 0.703, the sensitivity, specificity and accuracy of diagnosis of left ventricular diastolic dysfunction in PM and/or DM were 67%, 68% and 67%, respectively. CONCLUSION Cystatin C is associated with left ventricular diastolic dysfunction in PM and/or DM patients. The higher the level of cystatin C, the greater the possibility of left ventricular diastolic dysfunction, which has certain diagnostic value