脂蛋白相关磷脂酶A2与早发冠心病的相关性及其临床意义

目的研究早发冠心病患者的危险因素,探讨脂蛋白相关磷脂酶(Lp-PL) A2水平与早发冠心病的相关性及临床意义。方法选取因胸痛住院并行冠状动脉造影,确诊为早发冠心病的患者63例。选取同期行冠脉造影,血管管腔狭窄<50%的患者30例作为对照组。分析(Lp-PL) A2水平与GRACE风险评分和Gensini积分的相关性。Logistic回归分析早发冠心病的危险因素。结果①早发冠心病组的脂蛋白相关磷脂酶A2水平显著高于对照组(P <0. 05)。②早发冠心病患者的脂蛋白相关磷脂酶A2水平与Gensini积分、GRACE风险评分显著相关(r=0. 368,P <0. 05; r=0. 402,P <0. 05)。③Logistic回归结果显示(Lp-PL) A2水平是早发冠心病的独立相关因素(P <0. 05)。结论 (Lp-PL) A2水平是早发冠心病的独立相关因素,与冠状动脉病变严重程度呈正相关,对评估早发冠心病的风险具有重要的临床应用价值。

The correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance

AIM To study risk factors of patients with premature coronary heart disease and to investigate the correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance. METHODS 93 patients underwent coronary angiography were divided into premature coronary heart disease group (n=63) and a control group (coronary artery stenosis <50%, n=30). The Lp-PLA2 levels were investigated between the two groups and the relationship of Lp-PLA2 with risk of patients was studied. RESULTS Lp-PLA2 levels were significantly higher in premature coronary heart disease group than in the control group(P<0.05). Lp-PLA2 had a significant correlation with Gensini score (r=0.368,P<0.05) and GRACE risk score (r=0.402,P<0.05). Multivariate logistic regression analysis showed that Lp-PLA2 was independently associated with premature coronary heart disease (P<0.05). CONCLUSION Lp-PLA2 is independently associated with premature coronary heart disease and positively related with the severity of coronary artery and prognosis. Thus Lp-PLA2 can be used as a predictor of risk assessment in premature coronary heart disease patients.