| miRNA调控心肌梗死后心肌细胞凋亡的研究进展 |
| |
| 引用本文： | 余丽霞,王键.miRNA调控心肌梗死后心肌细胞凋亡的研究进展[J].心脏杂志,2019,31(2):227-231. |
| |
| 作者姓名： | 余丽霞 王键 |
| |
| 作者单位： | 华南理工大学医学院神经生物学实验室，广东 广州 510006 |
| |
| 摘 要： | miRNA是长度为21～23个核苷酸的非编码单链RNA小分子,可调节目标mRNA的稳定性和转录的效率,参与调控心肌梗死(MI)后心肌细胞凋亡的分子机制。成熟心肌细胞不可再生的特殊性,决定了抑制心肌细胞凋亡是治疗心血管疾病的重要突破口。本文依据miRNA转录后抑制多种心肌细胞的mRNA生物学特性,综述了miRNA与心肌细胞凋亡通路的关系,阐明miRNA在调控MI后心肌细胞凋亡的分子网络中的作用,为今后心血管疾病的诊治提供新思路和方法。
|
| 关 键 词： | MIRNA 心肌梗死 心肌细胞凋亡 分子机制 |
| 收稿时间： | 2018-12-25 |
Role of miRNA in regulation of cardiomyocyte apoptosis after myocardial infarction |
| |
| YU Li-xia,WANG Jian.Role of miRNA in regulation of cardiomyocyte apoptosis after myocardial infarction[J].Chinese Heart Journal,2019,31(2):227-231. |
| |
| Authors: | YU Li-xia WANG Jian |
| |
| Institution: | Neuro Biology Laboratory, School of Medicine, South China University of Technology, Guangzhou 510006, Guangdong, China |
| |
| Abstract: | miRNAs are endogenous 21~23-nucleotide (nt) noncoding RNAs that negatively regulate gene expression via degradation and translational inhibition of their target mRNAs. Recent studies have shown the molecular mechanisms of miRNAs involved in the regulation of cardiomyocyte apoptosis after myocardial infarction (MI). The non-renewable nature of mature cardiomyocytes determines that inhibition of cardiomyocyte apoptosis is an important breakthrough in the treatment of cardiovascular diseases. Based on the biological characteristics of miRNA, the role of miRNA in the molecular network of cardiomyocyte apoptosis after MI was elucidated in this paper, which may offer a new target for therapeutic intervention in patients with acute myocardial infarction. |
| |
| Keywords: | miRNA myocardial infarction cardiomyocyte apoptosis molecular mechanisms |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《心脏杂志》浏览原始摘要信息 |
| 点击此处可从《心脏杂志》下载免费的PDF全文 |
|
