Aporphine Alkaloids of Ocotea brenesii |
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| Authors: | José A López Wagner Barillas Jorge Gomez-Laurito Fu-Tyan Lin Adnan J Al-Rehaily Maged H M Sharaf |
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| Affiliation: | 1. Instituto de Investigaciones Farmacéuticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica, San Jose, Costa Rica;2. Escuela de Biologia, Universidad de Costa Rica, San José, Costa Rica;3. Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, U.S.A.;4. Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A. |
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| Abstract: | The aporphine alkaloids (+)-isocorydine, (-)-3-hydroxynuciferine, and 3-hydroxy-6a,7-dehydronuciferine were isolated from the alkaloid fraction of an ethanol extract of the leaves of Ocotea brenesii Standley. Although (+)-isocorydine has been isolated from extracts of several Ocotea species previously, this is the first reported isolation of (-)-3-hydroxynuciferine and 3-hydroxy-6a,7-dehydronuciferine from this genus. Finally, to our knowledge, this is the first reported isolation of (-)-3-hydroxynuciferine from nature, although the compound was previously synthesized from nuciferine. In addition, it is only the second reported isolation of 3-hydroxy-6a,7-dehydronuciferine from a higher plant. |
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| Keywords: | Ocotea brenesii Standley Lauraceae aporphine alkaloids (+)-isocorydine (-)-3-hydroxynuciferine 3-hydroxy-6a 7-dehydronuciferine |
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