308 nm准分子激光联合吡美莫司乳膏治疗儿童白癜风的疗效观察

目的 评价308 nm准分子激光联合吡美莫司乳膏治疗儿童白癜风的疗效及不良反应。 方法 随机选取49例皮损对称的稳定期儿童白癜风患者，采用自身对照方法，将对称的皮损随机分成A、B两组，A组：给予准分子激光照射，每周2次，疗程15周，联合外用吡美莫司乳膏，每日2次；B组：单独给予准分子激光照射，每周2次，疗程15周。分别于准分子激光治疗第15次及30次后进行疗效评价。结果 30次治疗结束后，A组显效率为77.1%，有效率为89.6%，B组显效率为52．1%，有效率为75.0%，A组有效率及显效率均显著优于B组（P ＝ 0.048，P ＝ 0.040）。两组不同部位皮损疗效比较，仅面部皮损予以联合治疗后显效率及有效率显著优于单用准分子激光治疗（P = 0.004）。结论 308 nm准分子激光对儿童白癜风是一项安全、有效的治疗方法，联合应用吡美莫司乳膏能增加面部皮损疗效。

Combination of 308 nm excimer laser with topical pimecrolimus cream for vitiligo in childhood

Objective To assess the efficacy and safety of 308 nm excimer laser plus topical pimeevaluated after 15 and 30 times of laser therapy respectively.Results Except for one patient,all patients were able to be evaluated for effiicacy.After 30 times of laser therapy,the response and excellent response rates were 89.6%and 77.1%respectively,in group A，5.0%and 52.1%respectively in group B;both rates were significantly higher in group A than in group B(both P＜0.05).Also,a highler repigmentation rate was obtained in facial lesions in group A compared with group B.Conclusions The 308 nm excimer laser is safe,erective and well-tolerated for vitiligo in childhood,and the combination with topical imecrolimus cream may improve its efficacy in facial vitiligo.