Molecular insights into gastrointestinal neuroendocrine tumours: importance and recent advances |
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Authors: | V D Corleto G Delle Fave R T Jensen |
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Institution: | Division of Digestive and Liver Diseases, University La Sapienza, Rome, Italy. |
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Abstract: | A subset of gastrointestinal neuroendocrine tumours (carcinoids and pancreatic endocrine tumours) show aggressive growth. Early identification of this subset is essential for management; however, clinical, laboratory and histologic features frequently fail to achieve this. Currently, there is an increased understanding of the molecular pathogenesis/changes in neuroendocrine tumours and this may identify important prognostic factors and possibly, new treatments. Recent findings and progress in this area are briefly reviewed in this article. |
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Keywords: | carcinoid gastrinoma Multiple Endocrine Neoplasia type-1 pancreatic endocrine tumour |
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