血浆纤维蛋白原、D-二聚体检测在骨创伤致深静脉血栓形成中的应用价值

目的:探讨纤维蛋白原(Fbg)、D-二聚体(D-Dimer)在骨创伤及手术造成的深静脉血栓形成(Deep VenousThrombosis,DVT)中的临床应用价值。方法:将骨创伤患者100例(骨创伤组)、DVT患者15例(DVT组)、正常人30例(对照组)及DVT患者用药前后进行分组,用PT导出法及散色比浊法测定Wog、D-Dimer含量。结果:骨创伤组、DVT组与对照组比较,Fbg、D-Dimer显著增高。不同骨创伤部位,尤其是下肢骨折、多发伤、关节置换术后的患者Fbg、D-Dimer的含量明显高于对照组,经统计学检验,具有显著性差异。同一组DVT患者用药前后Fbg、D-Dimer也有显著差异。结论:Fbg、D-Dimer检测对骨创伤及手术造成的DVT具有排除诊断价值。

Clinical Application of Fibrinogen and D-dimer in the Post-trauma DVT Patients

Objective: To investigate the clinical application of Fbg and D-Dimer in the prevention and treatment of DVT in post-trauma and post-operation patient. Method: Plasma obtained from four groups , 100 fracture patients(fracture group), 15 DVT patients (DVT group), 30 healthy persons (control group), and the post-treatment DVT group. Fbg and D-Dimer level was determined by used of method PT educe, dispersion and nephelometric analysis. Results: The Fbg and the D-Dimer values in the fracture group and DVT patients, especially in the lower limb fracture, multiple fracture and arthro-plasty patients are significantly higher than those of the control group. The Fbg and the D-Dimer of DVT patients decreased significantly after therapy. Conclusion: The level of Fbg and D-Dimer could be used to exclude DVT for the fracture patients with DVT risk.