2型糖尿病与钙,磷代谢及相关激素的关系

目的 观察２型糖尿病患者钙、磷代谢及相关激素的变化及对骨代谢的影响。方法 测定２０例健康对照者和６０例２型糖尿病患者血甲状旁腺素（ＰＴＨ）、降钙素（ＣＴ）、２５羟维生素Ｄ３「「２５（ＯＨ）Ｄ３」」、环磷酸腺苷（ｃＡＭＰ）和血、尿钙（Ｃａ）、磷（Ｐ）、镁（Ｍｇ），糖基化血红蛋白（ＨｂＡｌｃ）、２４ｈ尿和２４ｈ尿白蛋白定量等指标。结果 ２型糖尿病患者血ＰＴＨ水平显著高于对照组（Ｐ〈０．０１），ＣＴ水平

A Clinical Study on Calcium,Phosphorus Metabolism and Its Regulatory Hormones in Type 2 Diabetes Mellitus

Objective To observe the changes on calcium,phosphorus metabolism and its regulatory hormones in type 2 diabetes mellitus.Method Serums parathyroid hormone (PTH),calcitonin(CT),25 hydroxycholecalciferol D 3(25(OH)D 3),cyclic adenosine monophosphate (cAMP) and serums calcium( Ca),phosphorus(P),magnesium(Mg)and urinary Ca,P, Mg and glycosylated hemoglobin(HbAlc),24 hour urinary glucose excretion and 60 type 2 diabetic patients were mearsured.Result That PTH level was increased (P<0.01) and CT level was decreased in diabetic groups(P<0.01),and urinary Ca,Mg excretion was increased(P<0.01 and P<0.05);That the level of PTH was remarkably positively correlated with the HbAlc and urinary Ca (r=0.40,P<0.05 and r=0.83,P<0.001),and was remarkably negatively correlated with CT(r= - 0.74,P<0.01).Conclusion These results suggest that type 2 diabetic patients have Ca,Mg metabolism disorder and secondary PTH, CT changes were more remarkable in early duration.Poor glucose control accelerated the development and progression of bone metabolism disorder.