| 高效液相色谱法测定羟苯乙酯中水杨酸含量 |
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| 引用本文： | 张琰,陈文秋,余敏灵. 高效液相色谱法测定羟苯乙酯中水杨酸含量[J]. 中国药业, 2010, 19(4): 27-27 |
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| 作者姓名： | 张琰 陈文秋 余敏灵 |
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| 作者单位： | 1. 四川省眉山市人民医院,四川,眉山,620010
2. 四川省乐山食品药品检验所,四川,乐山,614000 |
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| 摘 要： | 目的建立测定羟苯乙酯中水杨酸含量的方法。方法采用反相高效液相色谱法，Diamonsil C18柱（250mm×4．6mm,5um），以0．05mol／L磷酸二氢钠缓冲液（pH=3．4）-乙腈（50：50）为流动相，检测波长为297nm。结果水杨酸质量浓度在0．51～13．26ug／mL范围内与峰面积呈良好的线性关系，平均回收率为99．0％，RSD=0．8％（n=6）。结论该法简便、准确、快速，适用于羟苯乙酯中水杨酸的含量测定。
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| 关 键 词： | 高效液相色谱法 羟苯乙酯 水杨酸 含量测定 |
Content Determination of Salicylic Acid in Ethylparaben by HPLC |
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| Zhang Yan,Chen Wenqiu,Yu Minling. Content Determination of Salicylic Acid in Ethylparaben by HPLC[J]. China Pharmaceuticals, 2010, 19(4): 27-27 |
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| Authors: | Zhang Yan Chen Wenqiu Yu Minling |
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| Affiliation: | 1. Meishan Municipal People＇ s Hospital Meishan, Sichuan, China 620010; 2. Leshan Municipal Institute for Food and Drug control, Leshan, Sichuan, China 614000) |
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| Abstract: | Objective To determine the content of salicylic acid in ethyparaben by HPLC. Methods The chromatographic column was Dia- monsil C18 column （250 mm ×4. 6 mm, 5 um） and the mobile phase was 0. 05 mol/L NAH2PO4（pH =3. d） -acetonitrile（50 ： 50）,the detective wavelength was 297 nm. Results It took the good linear relationship when the sample size of salicylic acid was within the range of 0.51- 13.26ug/mL. The average recovery rate was 99.0%, RSD =0. 8% （n =6）. Conclusion The methed is simple, accurate and fast, which can be used for the content determination of solicylic acid in ethylparaben. |
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| Keywords: | HPLC ethylparaben salicylic acid content determination |
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