| 小蘖胺对小鼠升白细胞作用机理的研究 |
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| 引用本文： | 李鹏飞,韩哲武. 小蘖胺对小鼠升白细胞作用机理的研究[J]. 内蒙古医学院学报, 1989, 0(2) |
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| 作者姓名： | 李鹏飞 韩哲武 |
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| 作者单位： | 内蒙古医学院药理学教研室，内蒙古医学院药理学教研室 |
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| 摘 要： | 本文采用小鼠体内扩散盒及脾结节法,结合骨髓有核细胞计数,探讨了小蘖胺对小鼠骨髓白细胞系造血功能的影响.该药能显著提高小鼠骨髓有核细胞数,量效关系显著,促进骨髓造血干细胞及粒系祖细胞的集落生成率.认为其作用机理与促进骨髓造血干细胞及粒系祖细胞的增殖、分化有关.
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| 关 键 词： | 小蘖胺 造血干细胞 粒系祖细胞 |
STUDY OF THE ACTION OF BERBAMINE ON LEUKOCYTOPOIESIS IN MICE |
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| Li Pengfei Han Zhewu. STUDY OF THE ACTION OF BERBAMINE ON LEUKOCYTOPOIESIS IN MICE[J]. Acta Academiae Medicinae Neimongol, 1989, 0(2) |
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| Authors: | Li Pengfei Han Zhewu |
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| Affiliation: | Department of Pharmacology |
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| Abstract: | Berbamine is an alkaloid isolated from Chinese traditional medicinal herb, Berberis soulieana Schneid.By using the endogenous spleen colony forming (CFU-S) tech- nique and the in vivo diffusion chamber (CFU-DC) culture method we demonstrated that berbamine possesses promoting action on the number of bone marrow nucleated cells and that of colonies formed by CFU-S and CFU-DC in mice.The results suggested that the granulopoietic action of berbamine may act through stimulating the proliferation and differentiation of CFU-S and CFU-DC. |
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| Keywords: | berbamine hemopoietic stem cell granular progenitor cell |
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