MDM2蛋白在宫颈癌中的表达及意义

目的 探讨MDM2蛋白在宫颈癌中的表达及意义.方法 用免疫组织化学EnVision法,检测37例宫颈鳞癌(SCC),16例宫颈腺癌(AUC),45例宫颈上皮内瘤样变 (CIN)及20例正常宫颈(NC)组织中MDM2蛋白的表达. 结果 MDM2蛋白在NC、CIN、AUC、SCC中的阳性率分别为0、13.33%(6/45)、43.75%(7/16)及43.24%(16/37).与正常宫颈及CIN组相比,MDM2蛋白在AUC、SCC组中的阳性率比较差异均有显著性(P＜0.01、P＜0.01、P＜0.05、P＜0.01);在不同分级的CIN、鳞癌及腺癌中MDM2蛋白阳性率比较差异无显著性(均P＞0.05). 结论 MDM2的表达可能与宫颈癌的发生、发展有关;MDM2蛋白表达可能与细胞分化程度无明显关系.

The expression of MDM2 protein and significance in cervical cancer

Objective To study the expression of MDM2 protein and the significance in cerival cancer.Methods Immunohistochemical technique(En Vision) was used to examine the expression of MDM2 protein in 37 cases of squamous carcinoma of the cervix(SCC),16 cases of adenocarcinoma of uterine cervix(AUC),45 cases of cervical intraepithelial neoplasia(CIN),and 20 cases of normal cervix(NC).Results The positive rates of MDM2 protein in NC,CIN,AUC and SCC were 0,13.33%,43.75% and 43.23%,respectively.The positive rates of MDM2 protein in SCC and AUC group were obviously higher than those in NC and CIN group.Within different differentiating hierarchy of CIN,SCC and AUC,there was no significance difference to the expression of MDM2 protein.Conclusion The expression of MDM2 protein might be related to the oncogenesis of cervical cancer.There might be no obvious relationship between the expression of MDM2 protein and the degree of cell differentiation.