经颅磁刺激安全性的实验研究

目的 :探讨重复经颅磁刺激的安全性。方法 :选用 3 6只健康Wistar大鼠 ,随机分为对照组 ,低频刺激组和高频刺激组 ,对低频组和高频组分别给予不同频率和强度的经颅磁刺激 ,然后对各组大鼠的行为、组织病理形态学、血清髓鞘碱性蛋白 (MBP)及神经元特异性烯醇化酶 (NSE)含量进行观察。结果 :低频刺激组 (5Hz)和高频刺激组 (2 0Hz)在刺激过程中均未出现异常活动 ,无肢体强直、阵挛等 ,脑组织形态学包括大体观察、普通光镜及电镜改变不明显 ,其血清MBP和NSE含量与正常对照组比较 ,差异无显著性意义 (P >0 0 5 )。结论 :在一定强度和频率内经颅磁刺激是一种比较安全的方法

Experimental study for safety of transcranial magnetic stimulation

Objective:To assess the safety of repetitive transcranial magnetic stimulation(TMS).Methods:Thirty-six Wistar rats were selected and were devided into control group,low frequency stimulation group and high frequency stimulation group randomly,and different frequency and intensity of repetitive TMS were applied to the low and high frequency stimulation group respectively.Then,the neurological behaviors,the morphopathological changes of the brain, the serum level of myelin basic protein(MBP) and neuron-specific enolase(NSE) were observed.Results:Both low frequency group and high frequency group didn't show abnormal activities,such as clonus, rigidity et al.No significant histological changes of rat brain were observed by naked eyes,light or electrical microscope.No statistically significant differences of serum mean MBP and NSE valuses of low and high frequency group was found as compared with the normal control(P>0.05).Conclusion:Repetitive TMS might be a safe method under the range of a certain intensity and frequency of stimulation.