| 缺血性心脑血管病的纤维蛋白原分子反应性的观察 |
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| 引用本文： | 马西. 缺血性心脑血管病的纤维蛋白原分子反应性的观察[J]. 中华血液学杂志, 1996, 17(3): 135-137 |
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| 作者姓名： | 马西 |
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| 作者单位： | 西安医科大学实验血液学研究室 |
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| 摘 要： | 应用计算机辅助分析研究了８０例冠心病、６０例血栓性脑血管病患者及６０名健康对照者血浆纤维蛋白单体聚合反应的动力学。发现患者组纤维蛋白单体聚合速率（ＦＭＰＶ）及ＦＭＰＶ与凝固性纤维蛋白原的比值均较对照组明显增高（Ｐ＜０．００１），表明纤维蛋白原分子反应性增强关系到纤维蛋白原分子结构变异。这可能是缺血性心脑血管病发病的重要因素
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| 关 键 词： | 计算机 纤维蛋白原 动脉硬化 冠心病 脑梗塞 |
Evaluationofthefibrinogenmolecularreactivityinpatientswithischaemiccardiocerebralvasculardisease |
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| MaXi.ResearchUnitforExperimentalHematology,XianMedicalUniversity,Xian. Evaluationofthefibrinogenmolecularreactivityinpatientswithischaemiccardiocerebralvasculardisease[J]. Chinese Journal of Hematology, 1996, 17(3): 135-137 |
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| Authors: | MaXi.ResearchUnitforExperimentalHematology XianMedicalUniversity Xian |
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| Affiliation: | MaXi.ResearchUnitforExperimentalHematology,XianMedicalUniversity,Xian,710061 |
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| Abstract: | ostudywhetherchangesofthefibrinogenmolecularreactivityoccurinischaemiccar-diocerebralvasculardisease,plasmafibrinogenfrom80patientswithcoronaryheartdisease,60patientswiththromboemboliccerebralvascularischaemicdiseaseand60healthysubjectswereanalyzedfortheconversionofthekineticsoffibrinogenintofibrinbyacomputerassistantprocedure.Thefibrinmonomerpolymerizationvelocity(FMPV)wasfoundtoberaisedsignificantlyinbothpatientgroupsascompared-withthoseofthecontrol(P<0.001).TheratioofFMPVtoclotablefibrinogen(asrepresentedbyAmax)wasalsomarkedlyelevatedinmostpatients(P<0.001).Itisconcludedthatincreasedfibrinogenmolecularreactivityisprobablyanimportantfactorinthepathogenesisoftheischaemiccardiocerebral-vasculardiseases.Thevariationinfibrinogenmolecularreactivitymustbeassociatedwithastructuralvariantoffibrinogen. |
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| Keywords: | ComputerFibrinogenAtherosclerosisCoronaryheartdiseaseCerebralinfarction |
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