| 小牛和大鼠肝生长刺激因子的提取及其对大鼠肝部分切除后肝细胞增殖的影响 |
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| 引用本文： | 邹清雁,向亚玲,陈德元,林堪,谢名荣. 小牛和大鼠肝生长刺激因子的提取及其对大鼠肝部分切除后肝细胞增殖的影响[J]. 解剖学杂志, 1992, 0(3) |
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| 作者姓名： | 邹清雁 向亚玲 陈德元 林堪 谢名荣 |
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| 作者单位： | 广州军区军医学校组胚教研室，广州军区军医学校组胚教研室，广州军区军医学校广州，广州军区军医学校组胚教研室，广州军区军医学校广州 广州 510315，广州 510315，510315微生物教研室，广州 510315，510315微生物教研室 |
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| 摘 要： | 从新生小牛肝及大鼠肝大部切除后的肝中用酒精反复沉淀和超滤方法提取肝生长刺激因子(HSS),利用32%肝部分切除后30小时的大鼠为检测模型研究HSS对大鼠再生肝细胞增殖的影响,结果发现,牛和鼠HSS均可使再生肝细胞分裂指数提高2～3倍,提示HSS可以促进肝细胞的分裂。牛HGS的剂量增加,其促肝细胞分裂的作用也随之增强。采用超滤法证明,HSS活性成分的分子量低于50KD。
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| 关 键 词： | 肝生长刺激因子 肝部分切除 肝细胞分裂 |
EFFECT OF HEPATIC STIMULATING SUBSTANCE (HSS) FROM RAT AND CALF ON MURINE HEPATOCYTE PROLIFERATIONAFTER PARTIAL HEPATECTOMY |
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| Zou Qingyan,Xian Yalin,Chen Dnyuan,Lin Kan,Xie Mingyun. EFFECT OF HEPATIC STIMULATING SUBSTANCE (HSS) FROM RAT AND CALF ON MURINE HEPATOCYTE PROLIFERATIONAFTER PARTIAL HEPATECTOMY[J]. Chinese Journal of Anatomy, 1992, 0(3) |
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| Authors: | Zou Qingyan Xian Yalin Chen Dnyuan Lin Kan Xie Mingyun |
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| Abstract: | The hepatic stimulating substance (HSS) was extrcted from the liver of new born calf and rat after 67% partial hepatectomy by the step of ethanol precipitation and ultrafiltration. The effect of HSS on the hepatocyte mitoses of rat was observed by using the assay model of the rat 30 hr after partial hepatectomy. The results show that both bovine and murine HSS can stimulate the regenerating hepatocyte mitoses rise to 2-3 times than that of control group, which indicate HSS can stimulate the hepatocyte division. The curve of HSS activity is rising with the increases of bovine HSS dose. It was found that the molecular weight of HSS to be at less than 50, 000 dalton by ultrafiltration. |
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| Keywords: | hepatic stimulating substance(HSS) partial hepatectomy hepatocyte mitosis. |
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