他扎罗汀乳膏治疗痤疮的临床疗效观察

目的:为痤疮患者提供更好的治疗方案。方法:122例痤疮患者按随机单盲对照原则分为他扎罗汀组(42例)、水氯酊组(38例)和联合治疗组(42例),连续外用8周后观察疗效。结果:3组皮损数均随治疗时间的延长而逐渐减少,与治疗前比较,治疗8周后皮损总分3组差异均有统计学意义(P<0.05或P<0.01)。治疗8周后有效率,他扎罗汀组与水氯酊组比较差异有统计学意义(χ2=17.629,P<0.05);联合治疗组与水氯酊组比较差异也有统计学意义(χ2=15.532,P<0.05);他扎罗汀组与联合治疗组比较差异无统计学意义(χ2=10.130,P>0.05)。结论:对于非炎症性痤疮可单用他扎罗汀治疗;对脓疱型患者水氯酊效果优于他扎罗汀,考虑与氯霉素的抗菌作用有关;而对于炎症性痤疮可选用他扎罗汀加0.5%水氯酊外用。

Clinical Application and Efficacy of Tazarotene Cream for Acne Vulgaris

OBJECTIVE： To provide optimal therapeutic scheme for patients with acne vulgaris. METHODS： By a sin- gle - blind randomized controlled method, a total of 122 patients with ache vulgaris were assigned to one of the following 3 groups ： tazarotene cream group（ n = 42）, Water chlorine tincture group（ n = 38） and combined treatment group（ n = 42）. The curative efficacy was observed after treatment for 8 consecutive weeks. RESULTS： The number of skin lesions in all the 3 groups reduced as the course of treatment increased, and there were significant differences across the 3 groups after 8- week treatment as compared with before treatment （P〈0.05 or P〈0.01） . After 8-week treatment, there were significant dif- ferences in responsive rate between tazarotene group and water chlorine tincture group（X^2= 17.629, P〈0.05） and between combined group and water chlorine tincture group（X^2= 15.532, P 〈 0.05）, but no significant differences were noted between tazarotene group and combined group（X^2= 10.130, P〉 0.05） . CONCLUSION： Tazarotene cream is effective for non-in- flammatory ache. The superior efficacy of water chlorine tincture as compared with tazarotene for patients with impetigo might be related to the antibacterial action of chloramphenicol. Tazarotene cream combined with local application of 0.5% water chlorine tincture is effective for inflammatory ache.