枳椇子乙酸乙酯提取部位的解酒作用研究

目的:研究枳椇子乙酸乙酯提取部位的解酒作用。方法:将小鼠随机分成5组,即空白、模型(生理盐水)、阳性(灌胃海王金樽20g·kg-1)和乙酸乙酯提取物高、低剂量组(乙酸乙酯提取物相当于20、10g生药.kg-1)。研究各种提取物对急性酒精中毒小鼠血清谷丙转氨酶(SGPT)活性、肝脏丙二醛(MDA)含量、醇脱氢酶(ADH)活性、还原型谷胱甘肽(GSH)含量、超氧化物歧化酶(SOD)活性的影响。结果:枳椇子乙酸乙酯提取部位可降低急性酒精中毒小鼠血清SGPT活性和肝脏MDA含量,升高小鼠肝脏ADH、SOD活性和GSH含量。结论:枳椇子乙酸乙酯提取部位具有显著的解酒效果,值得进行深入研究。

Effect of Ethyl Acetate Extract of the Seeds of Semem Hoveniae against Alcoholism

OBJECTIVE： To study on the effect of ethyl acetate extract of the seeds of Semem Hoveniae .against alcoholism. METHODES： The mice were divided into four groups： model group （i.g. normal saline）, positive group（i.g. Haiwangjinzun 20 g·kg^-1）, low- dose group of ethyl acetate extract （i.g. ethyl acetate extract 10 g · kg^-1）, and high - dose group of ethyl acetate extract （i .g. ethyl acetate extract 20 g · kg^-1） .The effects of different extracts on serum SGPT activity, MDA content and ADH activity, GSH content and SOD activity in liver tissue of mice with acute alcoholism were determined. RESULTS： Serum SGPT activity and MDA content were down - regulated while ADH activity, GSH content and SOD activity in liver tissue of acute alcoholism mice were up- regulated by the ethyl acetate extract of the seeds of Hovenia Dulcis Thunb. CONCLUSION： The ethyl acetate extract of the seeds of Semem Hoveniae exhibited remarkable anti - alcoholism efficacy, and which is worthy of further study.