注射用甲磺酸帕珠沙星与3种止血药在氯化钠注射液中配伍的稳定性考察

目的:考察注射用甲磺酸帕珠沙星与3种止血药在氯化钠注射液中配伍的稳定性。方法:分别在25℃、自然光环境下,模拟临床常用的浓度,考察注射用甲磺酸帕珠沙星与酚磺乙胺注射液、维生素K1注射液、氨甲苯酸注射液配伍8h内混合液的外观、pH值、不溶性微粒和甲磺酸帕珠沙星含量的变化。结果:注射用甲磺酸帕珠沙星与氨甲苯酸注射液及酚磺乙胺注射液混合,8h内混合液外观、pH值、不溶性微粒、含量均无明显改变;与维生素K1注射液混合时,2h内混合液外观、pH值、含量均无明显改变,但1h后不溶性微粒检查不合格,4h后出现白色沉淀,甲磺酸帕珠沙星含量也有所下降。结论:注射用甲磺酸帕珠沙星与氨甲苯酸及酚磺乙胺注射液配伍,室温下8h内性质稳定;注射用甲磺酸帕珠沙星与维生素K1注射液配伍则应慎重。

Compatible Stability of Pazufloxacin Mesilate for Injection with Three Kinds of Hemostatics in Sodium Chloride Injection

OBJECTIVE： To study compatible stability of pazufloxacin mesilate for injection with three kinds of hemostatics in sodium chloride injection. METHODS： Thechanges of the mixtures in appearance, pH values, insoluble particles and the content of pazufloxacin mesilate within 8 hours after mixing of pazuftoxacin injection with etamsylate, Vitamin K1 or aminomethylbenzoic at 25℃ under natural, illumination in a Simulated clinical common concentration were followed. RESULTS： There were no significant change in the appcarance, pH value and the content of pazufloxacin mesilate within 8 hours after mixing of pazufloxacin mesilate for injection with aminomethylhenzoic injection or etamsylate injection; when mixed with Vitamin K1, there were no significant change in the appearance, pH and the content of pazufloxacin mesilate within 2 hours, but the insoluble particles was found to be unqualified after 1 hour of mixing, and white precipitate appeared after 4 hours and the content of pazufloxaein mesilate decreased to some degree. CONCLUSION： The mixture of pazufloxaein mesilate for injection and etamsylate or aminomethylbenzoic was stable within 8 hours at room temperature. The mixing of pazufloxacin mesilate for injection with Vitamin K1 should be conducted with caution.