6种用药方案治疗化疗药物相关性肝损害的经济学评价

目的:评价6种用药方案治疗化疗药物相关性肝损害的经济学效果。方法:将应用化疗药物引起肝功能异常的269例恶性肿瘤患者随机分为A、B、C、D、E、F组,分别应用注射用还原型谷胱甘肽钠、甘草酸二铵注射液、复方甘草酸苷注射液、多烯磷脂酰胆碱注射液、复方二氯醋酸二异丙胺注射液、注射用复方甘草酸单铵S治疗,观察疗效,并进行成本-效果分析。结果:A、B、C、D、E、F组总有效率分别为91.67%、75.00%、86.05%、84.78%、87.50%、85.42%,成本分别为798.28、311.08、859.88、918.68、1092.28、1319.08元,成本-效果比分别为870.82、414.77、999.28、1083.60、1248.32、1544.23;A、C、D、E、F组相对于B组的增量成本-效果比分别为2922.62、4966.52、6212.68、6249.60、9673.70。结论:A组方案为治疗化疗药物相关性肝损害安全、有效、经济的方案。

Economic Evaluation on 6 Therapeutic Schemes for Hepatic Lesion Induced by Chemotherapeutic Drugs

OBJECTIVE： To evaluate the economic efficacy of 6 therapeutic schemes for hepatic lesions induced by chemotherapeutic drugs. METHODS： A total of 269 malignant tumor patients complicating hepatic lesion because of using of chemotherapeutic drugs were randomly divided into 6 groups （A, B, C, D, E and F） to be treated with Reduced Glutathione Sodium for Injection, Diammonium Glycyrrhizinate Injection, Compound Glyeyrrhizin Injection, Polyene Phosphatidylcholine Injection, Compound Diisopropylamine Dichloroacetate Injection, Compound Ammonium Glycyrrhetate Injection, respective- ly. The curative effects were recorded and the cost- effectiveness analysis was conducted. RESULTS： In A, B, C, D, E and F groups, the effective rates were 91.67%, 75.00%, 86.05%, 84.78%, 87.50% and 85.42%, respectively, the costs were 798.28 yuan, 311,08 yuan, 859.88 yuan, 918.68 yuan, 1 092.28 yuan and 1 319.08 yuan, respectively, and the cost - effec- tiveness ratios were： 870.82, 414.77, 999.28, 1 083.60, 1 248.32 and i 544.23, respectively. The incremental cost - effec- tiveness ratios for A, C, D, E, F groups as against group B were 2 922.62, 4 966.52, 6 212.68, 6 249.60 and 9 673.70, re- spectively. CONCLUSION： Group A was proved to be the safe, effective and economical therapeutic scheme for hepatic lesions induced by chemotherapeutic drugs.