葛根素注射剂致溶血反应44例分析

目的:了解葛根素注射剂致溶血反应的发生规律、相关因素和预后情况。方法:对国内1994年以来有关葛根素注射剂致溶血反应的病例报道26篇44例进行分析。结果:44例中男性31例,女性13例,平均年龄(67.5±9.6)a;葛根素注射液和注射用葛根素均有溶血反应发生,平均用药剂量(445.2±123.8)mg,平均输液浓度(1.55±0.52)mg·mL~(-1);溶血反应多发生于连续用药1周以上,平均时间为(7.96±3.84)d,以急性溶血性贫血为主要表现,血液免疫学检查可见葛根素特异性抗体。死亡10例,其中男性9例,女性1例,平均年龄(72.1±5.7)a。结论:葛根素注射剂致溶血反应的发生和转归与多种因素有关,应引起高度重视。

Puerarin Injection - induced Hemolytic Reactions： Literature Analysis of 44 Cases

OBJECTIVE： To probe into the regular pattern, related factors and prognosis of hemolytic reactions induced by Puerarin injection. METHODS： A total of 44 hemolytic cases induced by Puerarin injection reported in 26 papers of domestic journals published since 1994 were analyzed. RESULTS： Of the 44 cases collected, 31 were males and 13 females, with a mean age of（67.5 ＋ 9.6） years. The hemolytic reactions were induced either by Puerarin injection or Puerarin for injection with a mean dose of（445.2＋ 123.8）mg and a mean concentration of puerarin （in infusion） of （1.55＋0.52） mg·mL^-1. The hemolytic reactions occurred chiefly after administration of puerarin for 7 consecutive days （7.96＋ 3.84 days on average） and appeared as acute hemolytic anemia. The puerarin specific antibody was noted in immunological test. 10 patients including 9 males and 1 male died at a mean age of（72.1 ＋ 5.7） years. CONCLUSION： The occurrence and turnover of Puerarin Injection-induced hemolytic reactions are related to many factors, to which great attention should be naid.