头孢哌酮/他唑巴坦钠在含果糖氯化钠注射液和转化糖注射液中的稳定性考察

目的:考察头孢哌酮/他唑巴坦钠在含果糖氯化钠注射液和转化糖注射液中的稳定性。方法:采用高效液相色谱(HPLC)法测定头孢哌酮/他唑巴坦钠与含果糖氯化钠注射液和转化糖注射液配伍6h内的含量,并考察其外观、pH值变化。结果:头孢哌酮/他唑巴坦钠与2种注射液配伍后,6h内其含量变化不大,溶液澄清,pH值基本稳定。结论:头孢哌酮/他唑巴坦钠可与含果糖氯化钠注射液和转化糖注射液配伍使用。

Stability of Cefoperazone Sodium / Tazobactam Sodium for Injections in Fructose - contained Sodium Chloride Injection or Invertose Injection

OBJECTIVE： To study the stability of Cefoperazone Sodium / Tazobactam Sodium in Fructose - contained 0.9% sodium chloride injection or Invertose Injection. METHODS： The contents of Cefoperazone Sodium / Tazobactam Sodium within 6 hours after mixing with Fructose-contained 0.9% sodium chloride injection or Invertose Injection were determined by HPLC, meanwhile the changes in the appearances and the pH values were observed. RESULTS： The contents of Cefoperazone Sodium and Tazobactam Sodium in Fructose-contained 0.9% sodium chloride injection or Invertose Injection were stable within 6 hours, and the mixed solutions were clear and their pH values were stable on the whole. CONCLUSION： Cefoperazone Sodium / Tazobactam Sodium can de mixed with Fructose-contained 0.9% sodium chloride injection or Invertose Injection for clinical use.