利用Excel规划求解法计算药物静脉注射药动学方程参数最优解

目的:利用Excel规划求解功能建立一种简便的计算药物静脉注射药动学方程参数最优解的方法。方法:采用Excel规划求解功能获得药物静脉注射后一、二室模型药动学参数和隔室模型参数,并与DAS和残数法得到的结果进行比较。结果:Excel规划求解可在一定约束条件下获得一、二室模型参数的最优解,与DAS运行结果完全一致。结论:Excel规划求解法可用于临床药物静脉注射后一、二室模型参数的计算。

Calculation of Optimal Pharmacokinetic - equation Parameters in Drugs by Intravenous Administration Using Excel Programming Solution

OBJECTIVE： To establish a simple method for calculating the optimal pharmacokinetic- equation parameters in drugs by intravenous administration using Excel programming solution. METHODS： The pharmacokinetic parameters and compartment model parameters after intravenous injection drugs were computed by means of Excel programming solution, and the results were compared with those computed by DAS method or residual method. RESULTS： By means of Excel programming solution, the optimal pharmacokinetic parameters of one- and two- compartment models were obtained, which were completely in line with those computed by DAS program. CONCLUSION： Excel programming solution is applicable for the computation of the pharmacokinetic parameters of one - and two - compartment models following intravenous injection drugs.